{"created":"2021-03-01T06:32:55.412166+00:00","id":24928,"links":{},"metadata":{"_buckets":{"deposit":"ea22e627-e6e1-410d-a6fd-dec74b536d8a"},"_deposit":{"id":"24928","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24928"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00024928","sets":["643:666:667"]},"author_link":["74257","74258","74259","74260","74261"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicPageEnd":"9111","bibliographicPageStart":"9097","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"The Journal of Organic Chemistry","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"De novo synthesis of possible candidates for the Inagami–Tamura endogenous digitalis-like factor (EDLF) was achieved to validate a previously proposed structure. Our synthetic approach involves a highly regio- and diastereoselective Mizoroki–Heck reaction and a Friedel–Crafts-type cyclodehydration to construct steroidal tetracycle 14 as a versatile common intermediate leading to seven 2,14β-dihydroxyestradiol analogues 1a–c, 2a–c, and 3 as possible candidates. By comparing the potency of inhibitory activity against Na+/K+-ATPase between the synthesized candidates and the EDLF, it was found that the proposed structure is not likely to be a true structure of the Inagami–Tamura EDLF.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1021/acs.joc.7b01640"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/27149"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1021/acs.joc.7b01640","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This document is the Accepted Manuscript version of a Published Work that appeared in final form in [The Journal of Organic Chemistry], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [http://pubs.acs.org/articlesonrequest/AOR-4SXiUUWhVWXaJhUPs93D].”","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-3263","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakazaki, Atsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Ai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikawa, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74261","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-01"}],"displaytype":"detail","filename":"revised_manuscript.pdf","filesize":[{"value":"609.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"revised_manuscript.pdf ファイル公開：2018/09/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/24928/files/revised_manuscript.pdf"},"version_id":"ec832f73-194c-4c52-867c-59de46afe628"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"De Novo Synthesis of Possible Candidates for the Inagami–Tamura Endogenous Digitalis-like Factor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"De Novo Synthesis of Possible Candidates for the Inagami–Tamura Endogenous Digitalis-like Factor","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["667"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-12-07"},"publish_date":"2017-12-07","publish_status":"0","recid":"24928","relation_version_is_last":true,"title":["De Novo Synthesis of Possible Candidates for the Inagami–Tamura Endogenous Digitalis-like Factor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:14:14.478909+00:00"}