{"created":"2021-03-01T06:32:55.613344+00:00","id":24931,"links":{},"metadata":{"_buckets":{"deposit":"d0fbdb11-ef3d-49fc-b20c-e88f2985102e"},"_deposit":{"id":"24931","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24931"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00024931"},"item_10_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1267","bibliographicPageStart":"1261","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"BONE MARROW TRANSPLANTATION"}]}]},"item_10_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"To investigate better GVHD prophylaxis in reduced intensity conditioning umbilical cord blood transplantation (RIC-UCBT), we compared transplant outcomes after UCBT among GvHD prophylaxes using the registry data. We selected patients transplanted for AML or ALL with a calcineurin inhibitor and methotrexate (MTX)/mycophenolate mofetil (MMF) combination. A total of 748 first RIC-UCBT between 2000 and 2012 (MTX+ group, 446, MMF+ group, 302) were included. The cumulative incidence of neutrophil and platelet counts higher than 50\u2009000/\u03bcL was significantly better in the MMF+ group (relative risk (RR), 1.55; P<0.001: RR, 1.34; P=0.003, respectively). In multivariate analyses, the risk of grade II\u2013IV and III\u2013IV acute GvHD was significantly higher in the MMF+ group than in the MTX+ group (RR, 1.75; P<0.001: RR, 1.97; P=0.004, respectively). In disease-specific analyses of AML, the risk of relapse of high-risk disease was significantly lower in the MMF+ group (RR, 0.69; P=0.009), whereas no significant difference was observed in the risk of relapse-free and overall survival in high-risk disease. In patients with standard-risk disease, no significant differences were noted in the risk of relapse or survival between the MTX+ and MMF+ groups. Collectively, these results suggest that MMF-containing prophylaxis may be preferable in RIC-UCBT, particularly for high-risk disease.","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1038/bmt.2017.116"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/27153"}]},"item_10_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"nature"}]},"item_10_select_15":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0268-3369","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Terakura, Seitaro"}],"nameIdentifiers":[{"nameIdentifier":"74276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwatsuka, Yachiyo"}],"nameIdentifiers":[{"nameIdentifier":"74277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"74278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wake, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"74279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanda, Junya"}],"nameIdentifiers":[{"nameIdentifier":"74280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inamoto, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"74281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizuta, Shuichi"}],"nameIdentifiers":[{"nameIdentifier":"74282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Takuhiro"}],"nameIdentifiers":[{"nameIdentifier":"74283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchida, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"74284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kouzai, Yasuji"}],"nameIdentifiers":[{"nameIdentifier":"74285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aotsuka, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"74286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Hiroyasu"}],"nameIdentifiers":[{"nameIdentifier":"74287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanamori, Heiwa"}],"nameIdentifiers":[{"nameIdentifier":"74288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiwaki, Kaichi"}],"nameIdentifiers":[{"nameIdentifier":"74289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyakoshi, Shigesaburo"}],"nameIdentifiers":[{"nameIdentifier":"74290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Onizuka, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"74291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amano, Itsuto"}],"nameIdentifiers":[{"nameIdentifier":"74292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuda, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"74293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichinohe, Tatsuo"}],"nameIdentifiers":[{"nameIdentifier":"74294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuta, Yoshiko"}],"nameIdentifiers":[{"nameIdentifier":"74295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"74296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Teshima, Takanori"}],"nameIdentifiers":[{"nameIdentifier":"74297","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-12"}],"displaytype":"detail","filename":"18558_1_merged_1491317774.pdf","filesize":[{"value":"608.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18558_1_merged_1491317774.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\u65e5:2017/12/12","url":"https://nagoya.repo.nii.ac.jp/record/24931/files/18558_1_merged_1491317774.pdf"},"version_id":"1caca25e-4de4-492c-8899-dfa6dfdedcec"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Graft-versus-host disease","subitem_subject_scheme":"Other"},{"subitem_subject":"GVHD prophylaxis","subitem_subject_scheme":"Other"},{"subitem_subject":"immunosuppressant selection","subitem_subject_scheme":"Other"},{"subitem_subject":"reduced intensity","subitem_subject_scheme":"Other"},{"subitem_subject":"single-unit umbilical cord blood transplantation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia"}]},"item_type_id":"10","owner":"1","path":["499/500/501"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2017-12-07"},"publish_date":"2017-12-07","publish_status":"0","recid":"24931","relation_version_is_last":true,"title":["GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T13:49:50.679827+00:00"}