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Gene Expression Profiling of Granule Cells and Purkinje Cells in the Zebrafish Cerebellum
http://hdl.handle.net/2237/27169
http://hdl.handle.net/2237/27169457ac199-9804-49fd-8afb-05267045ee34
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-12-12 | |||||
| タイトル | ||||||
| タイトル | Gene Expression Profiling of Granule Cells and Purkinje Cells in the Zebrafish Cerebellum | |||||
| 言語 | en | |||||
| 著者 |
Takeuchi, Miki
× Takeuchi, Miki× Yamaguchi, Shingo× Sakakibara, Masayoshi× Hayashi, Takuto× Matsuda, Koji× Hara, Yuichiro× Tanegashima, Chiharu× Shimizu, Takashi× Kuraku, Shigehiro× Hibi, Masahiko |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the peer reviewed version of the following article: [Journal of Comparative Neurology. v.525, n.7, 2017, p.1558-1585], which has been published in final form at [http://doi.org/10.1002/cne.24114/]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RNA-seq | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebellar gene enrichment | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebellum-like structures | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RRID:ZIRC_ZL1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RRID: AB_10013361 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RRID: SCR_001370 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RRID: SCR_001120 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The structure of the neural circuitry of the cerebellum, which functions in some types of motor learning and coordination, is generally conserved among vertebrates. However, some cerebellar features are species-specific. It is not clear which genes are involved in forming these conserved and species-specific structures and functions. Here, using zebrafish transgenic larvae expressing fluorescent proteins in granule cells, Purkinje cells, or other cerebellar neurons and glial cells, we isolated each type of cerebellar cells by fluorescence-activated cell sorting and profiled their gene expressions by RNA sequencing and in situ hybridization. We identified genes that were upregulated in granule cells or Purkinje cells, including many genes that are also expressed in mammalian cerebella. A comparison of the transcriptomes in granule cells and Purkinje cells in zebrafish larvae revealed that more developmental genes are expressed in granule cells, whereas more neuronal-function genes are expressed in Purkinje cells. We further found that some genes that are upregulated in granule cells or Purkinje cells are also expressed in the cerebellum-like structures. Our data provide a platform for understanding the development and function of the cerebellar neural circuits in zebrafish, and the evolution of cerebellar circuits in vertebrates. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/cne.24114 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0021-9967 | |||||
| 書誌情報 |
en : Journal of Comparative Neurology 巻 525, 号 7, p. 1558-1585, 発行日 2017-05-01 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1002/cne.24114 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27169 | |||||
| 識別子タイプ | HDL | |||||
