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Crystal structure of human WBSCR16, an RCC1-like protein in mitochondria
http://hdl.handle.net/2237/27173
http://hdl.handle.net/2237/27173e74e4370-7142-403c-b386-f39ba4198329
| 名前 / ファイル | ライセンス | アクション |
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koyama2017ProtSci_for_depository3.pdf ファイル公開日:2018/09/01 (881.2 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-12-19 | |||||
| タイトル | ||||||
| タイトル | Crystal structure of human WBSCR16, an RCC1-like protein in mitochondria | |||||
| 言語 | en | |||||
| 著者 |
Koyama, Masako
× Koyama, Masako× Sasaki, Taeko× Sasaki, Narie× Matsuura, Yoshiyuki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | This is the peer reviewed version of the following article: [Koyama, M., Sasaki, T., Sasaki, N. and Matsuura, Y. (2017), Crystal structure of human WBSCR16, an RCC1-like protein in mitochondria. Protein Science, 26: 1870–1877], which has been published in final form at [http://doi.org/10.1002/pro.3210]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | WBSCR16 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RCC1-like protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Williams-Beuren syndrome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mitochondrial translation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mitoribosome | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | WBSCR16 (Williams-Beuren Syndrome Chromosomal Region 16) gene is located in alarge deletion region of Williams-Beuren syndrome (WBS), which is a neurodevelopmental disorder.Although the relationship between WBSCR16 and WBS remains unclear, it has been reported thatWBSCR16 is a member of a functional module that regulates mitochondrial 16S rRNA abundanceand intra-mitochondrial translation. WBSCR16 has RCC1 (Regulator of Chromosome Condensation1)-like amino acid sequence repeats but the function of WBSCR16 appears to be different fromthat of other RCC1 superfamily members. Here, we demonstrate that WBSCR16 localizes to mito-chondria in HeLa cells, and report the crystal structure of WBSCR16 deter mined to 2.0 A˚resolutionusing multi-wavelength anomalous diffraction. WBSCR16 adopts the seven-bladed b-propeller foldcharacteristic of RCC1-like proteins. A comparison of the WBSCR16 structure with that of RCC1and other RCC1-like proteins reveals that, although many of the residues buried in the core of theb-propeller are highly conserved, the surface residues are poorly conserved and conformationally divergent. | |||||
| 言語 | en | |||||
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| 出版者 | Wiley | |||||
| 言語 | en | |||||
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| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/pro.3210 | |||||
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| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0961-8368 | |||||
| 書誌情報 |
en : PROTEIN SCIENCE 巻 26, 号 9, p. 1870-1877, 発行日 2017-09 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1002/pro.3210 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27173 | |||||
| 識別子タイプ | HDL | |||||
