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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still’s disease

http://hdl.handle.net/2237/27254
http://hdl.handle.net/2237/27254
265ea809-2906-45c7-b01d-dbc5e03a8038
名前 / ファイル ライセンス アクション
Slide_1.tif Slide_1.tif ファイル公開日:2018/10/01 (1.2 MB)
Figure_02_03-14-17_trimed.tif Figure_02_03-14-17_trimed.tif ファイル公開日:2018/10/01 (482.0 kB)
AOSD_Main_text_03-14-17.pdf AOSD_Main_text_03-14-17.pdf ファイル公開日:2018/10/01 (123.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-10
タイトル
タイトル Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still’s disease
言語 en
著者 TAKEICHI, Takuya

× TAKEICHI, Takuya

WEKO 74627

en TAKEICHI, Takuya

Search repository
WATANABE, Naoki

× WATANABE, Naoki

WEKO 74628

en WATANABE, Naoki

Search repository
MURO, Yoshinao

× MURO, Yoshinao

WEKO 74629

en MURO, Yoshinao

Search repository
TESHIGAWARA, Shiho

× TESHIGAWARA, Shiho

WEKO 74630

en TESHIGAWARA, Shiho

Search repository
SATO, Motoki

× SATO, Motoki

WEKO 74631

en SATO, Motoki

Search repository
BAN, Nobutaro

× BAN, Nobutaro

WEKO 74632

en BAN, Nobutaro

Search repository
AKIYAMA, Masashi

× AKIYAMA, Masashi

WEKO 74633

en AKIYAMA, Masashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [ Takeichi, T; Watanabe, N; Muro, Y; Teshigawara, S; Sato, M; Ban, N; Akiyama, M(2017),Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. JOURNAL OF DERMATOLOGY, 44, 10: p.1172-1175], which has been published in final form at [http://doi.org/10.1111/1346-8138.13888]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
キーワード
主題Scheme Other
主題 adult-onset Still’s disease
キーワード
主題Scheme Other
主題 epidermis
キーワード
主題Scheme Other
主題 immunohistochemistry
キーワード
主題Scheme Other
主題 keratinocyte
キーワード
主題Scheme Other
主題 signal transducer
抄録
内容記述 Adult-onset Still's disease (AOSD) is characterized by multiple systemic inflammation of unknown etiology. Although the typical eruption of AOSD is salmon-pink rheumatoid rash on the trunk and extremities, persistent pruritic papules and plaques have also been reported. Correlations between serum cytokines, including interleukin-6 and -18, and disease activity in AOSD have been reported. Activated signal transducer and activator of transcription 3 (STAT3) is transported into the nucleus, where it functions as a transcription factor that regulates genes involved in cell survival and inflammation. To assess whether STAT3 was phosphorylated in skin samples from AOSD patients, we conducted immunohistochemical analysis of affected and unaffected lesions from four AOSD patients in comparison with 10 normal controls. Quantitative analysis was conducted by measuring the ratio of epidermal keratinocytes with phosphorylated STAT3 (p-STAT3)-positive nuclei to total epidermal keratinocytes. p-STAT3 was found to be more strongly expressed in the nuclei in the epidermis of AOSD than in normal controls. Quantification of the data revealed significant differences in staining for p-STAT3 between AOSD and normal skin. Our findings suggest that phosphorylation of STAT3 may be a potential therapeutic target for AOSD.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/1346-8138.13888
ISSN
収録物識別子タイプ PISSN
収録物識別子 0385-2407
書誌情報 en : JOURNAL OF DERMATOLOGY

巻 44, 号 10, p. 1172-1175, 発行日 2017-10
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1111/1346-8138.13888
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27254
識別子タイプ HDL
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