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Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still’s disease
http://hdl.handle.net/2237/27254
http://hdl.handle.net/2237/27254265ea809-2906-45c7-b01d-dbc5e03a8038
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Slide_1.tif ファイル公開日:2018/10/01 (1.2 MB)
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Figure_02_03-14-17_trimed.tif ファイル公開日:2018/10/01 (482.0 kB)
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AOSD_Main_text_03-14-17.pdf ファイル公開日:2018/10/01 (123.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-10 | |||||
タイトル | ||||||
タイトル | Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still’s disease | |||||
言語 | en | |||||
著者 |
TAKEICHI, Takuya
× TAKEICHI, Takuya× WATANABE, Naoki× MURO, Yoshinao× TESHIGAWARA, Shiho× SATO, Motoki× BAN, Nobutaro× AKIYAMA, Masashi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the peer reviewed version of the following article: [ Takeichi, T; Watanabe, N; Muro, Y; Teshigawara, S; Sato, M; Ban, N; Akiyama, M(2017),Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. JOURNAL OF DERMATOLOGY, 44, 10: p.1172-1175], which has been published in final form at [http://doi.org/10.1111/1346-8138.13888]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adult-onset Still’s disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epidermis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | keratinocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | signal transducer | |||||
抄録 | ||||||
内容記述 | Adult-onset Still's disease (AOSD) is characterized by multiple systemic inflammation of unknown etiology. Although the typical eruption of AOSD is salmon-pink rheumatoid rash on the trunk and extremities, persistent pruritic papules and plaques have also been reported. Correlations between serum cytokines, including interleukin-6 and -18, and disease activity in AOSD have been reported. Activated signal transducer and activator of transcription 3 (STAT3) is transported into the nucleus, where it functions as a transcription factor that regulates genes involved in cell survival and inflammation. To assess whether STAT3 was phosphorylated in skin samples from AOSD patients, we conducted immunohistochemical analysis of affected and unaffected lesions from four AOSD patients in comparison with 10 normal controls. Quantitative analysis was conducted by measuring the ratio of epidermal keratinocytes with phosphorylated STAT3 (p-STAT3)-positive nuclei to total epidermal keratinocytes. p-STAT3 was found to be more strongly expressed in the nuclei in the epidermis of AOSD than in normal controls. Quantification of the data revealed significant differences in staining for p-STAT3 between AOSD and normal skin. Our findings suggest that phosphorylation of STAT3 may be a potential therapeutic target for AOSD. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Wiley | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/1346-8138.13888 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0385-2407 | |||||
書誌情報 |
en : JOURNAL OF DERMATOLOGY 巻 44, 号 10, p. 1172-1175, 発行日 2017-10 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1111/1346-8138.13888 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/27254 | |||||
識別子タイプ | HDL |