{"created":"2021-03-01T06:33:05.965960+00:00","id":25091,"links":{},"metadata":{"_buckets":{"deposit":"3e4bb10b-7f82-470b-8ca3-7720ba2581ff"},"_deposit":{"id":"25091","owners":[],"pid":{"revision_id":0,"type":"depid","value":"25091"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00025091","sets":["499:500:501"]},"author_link":["74823","74824","74825","74826","74827","74828","74829","74830","74831","74832","74833","74834"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"574","bibliographicPageStart":"564","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"PATHOLOGY INTERNATIONAL","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26.7%) in Mutyh-deficient mice in comparison to wild-type mice (7.1%). Fe-NTA treatment also induced renal malignant lymphoma, which did not occur without the Fe-NTA treatment in both the genotypes. Renal tumor-free survival after Fe-NTA treatment was marginally different (P = 0.157) between the two genotypes. Array-based comparative genome hybridization analyses revealed, in RCC, the loss of heterozygosity in chromosomes 4 and 12 without p16INK[4]A inactivation; these results were confirmed by a methylation analysis and showed no significant difference between the genotypes. Lymphomas showed a preference for genomic amplifications. Dlk1 inactivation by promoter methylation may be involved in carcinogenesis in both tumors. Fe-NTA-induced murine RCCs revealed significantly less genomic aberrations than those in rats, demonstrating a marked species difference.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1111/pin.12598"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/27310"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/pin.12598","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: [Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. and Toyokuni, S.(2017), Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.PATHOLOGY INTERNATIONAL.,67: 564–574. doi:10.1111/pin.12598], which has been published in final form at [http://doi.org/10.1111/pin.12598]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1320-5463","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Li, Guang Hua","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akatsuka, Shinya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chew, Shan Hwu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jiang, Li","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakamoto, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Futakuchi, Mitsuru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakumi, Kunihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakabeppu, Yusaku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyokuni, Shinya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74834","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-01"}],"displaytype":"detail","filename":"deposit_1.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"deposit_1.pdf ファイル公開日:2018/11/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/25091/files/deposit_1.pdf"},"version_id":"131d57dc-2412-4d2a-b225-b801f451342b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-30"},"publish_date":"2018-01-30","publish_status":"0","recid":"25091","relation_version_is_last":true,"title":["Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:15:51.091586+00:00"}