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Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
http://hdl.handle.net/2237/27316
http://hdl.handle.net/2237/273168f07786b-d428-43e7-9e3f-ddf3b2973f21
名前 / ファイル | ライセンス | アクション |
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20170715shoji_1_revise_shisaka_shoji20170910-1.pdf ファイル公開日:2018/11/27 (3.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-30 | |||||
タイトル | ||||||
タイトル | Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group | |||||
言語 | en | |||||
著者 |
Uehara, Hiromu
× Uehara, Hiromu× Shisaka, Yuma× Nishimura, Tsubasa× Sugimoto, Hiroshi× Shiro, Yoshitsugu× Miyake, Yoshihiro× Shinokubo, Hiroshi× Watanabe, Yoshihito× Shoji, Osami |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the peer reviewed version of the following article: [H. Uehara, Y. Shisaka, T. Nishimura, H. Sugimoto, Y. Shiro, Y. Miyake, H. Shinokubo, Y. Watanabe, O. Shoji, Angew. Chem. Int. Ed. 2017, 56, 15279.], which has been published in final form at [http://doi.org/10.1002/anie.201707212]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | synthetic porphyrins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heme proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | artificial HasA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein structures | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth inhibition | |||||
抄録 | ||||||
内容記述 | ron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Wiley | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/anie.201707212 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1433-7851 | |||||
書誌情報 |
en : ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 巻 56, 号 48, p. 15279-15283, 発行日 2017-11-27 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1002/anie.201707212 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/27316 | |||||
識別子タイプ | HDL |