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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group

http://hdl.handle.net/2237/27316
8f07786b-d428-43e7-9e3f-ddf3b2973f21
名前 / ファイル ライセンス アクション
20170715shoji_1_revise_shisaka_shoji20170910-1.pdf 20170715shoji_1_revise_shisaka_shoji20170910-1.pdf ファイル公開日:2018/11/27 (3.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-30
タイトル
タイトル Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
著者 Uehara, Hiromu

× Uehara, Hiromu

WEKO 74870

Uehara, Hiromu

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Shisaka, Yuma

× Shisaka, Yuma

WEKO 74871

Shisaka, Yuma

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Nishimura, Tsubasa

× Nishimura, Tsubasa

WEKO 74872

Nishimura, Tsubasa

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Sugimoto, Hiroshi

× Sugimoto, Hiroshi

WEKO 74873

Sugimoto, Hiroshi

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Shiro, Yoshitsugu

× Shiro, Yoshitsugu

WEKO 74874

Shiro, Yoshitsugu

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Miyake, Yoshihiro

× Miyake, Yoshihiro

WEKO 74875

Miyake, Yoshihiro

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Shinokubo, Hiroshi

× Shinokubo, Hiroshi

WEKO 74876

Shinokubo, Hiroshi

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Watanabe, Yoshihito

× Watanabe, Yoshihito

WEKO 74877

Watanabe, Yoshihito

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Shoji, Osami

× Shoji, Osami

WEKO 74878

Shoji, Osami

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権利
権利情報 This is the peer reviewed version of the following article: [H. Uehara, Y. Shisaka, T. Nishimura, H. Sugimoto, Y. Shiro, Y. Miyake, H. Shinokubo, Y. Watanabe, O. Shoji, Angew. Chem. Int. Ed. 2017, 56, 15279.], which has been published in final form at [http://doi.org/10.1002/anie.201707212]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
キーワード
主題Scheme Other
主題 synthetic porphyrins
キーワード
主題Scheme Other
主題 heme proteins
キーワード
主題Scheme Other
主題 artificial HasA
キーワード
主題Scheme Other
主題 protein structures
キーワード
主題Scheme Other
主題 growth inhibition
抄録
内容記述 ron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency.
内容記述タイプ Abstract
出版者
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1433-7851
書誌情報 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

巻 56, 号 48, p. 15279-15283, 発行日 2017-11-27
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/anie.201707212
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27316
識別子タイプ HDL
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