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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Identification of NCCRP1 as an epigenetically regulated tumor suppressor and biomarker for malignant phenotypes of squamous cell carcinoma of the esophagus

http://hdl.handle.net/2237/27335
http://hdl.handle.net/2237/27335
dc9340b5-9153-4b5e-bc39-6e5785a2113c
名前 / ファイル ライセンス アクション
ol_14_4_4822_PDF.pdf ol_14_4_4822_PDF.pdf ファイル公開日:2018/04/01 (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-31
タイトル
タイトル Identification of NCCRP1 as an epigenetically regulated tumor suppressor and biomarker for malignant phenotypes of squamous cell carcinoma of the esophagus
言語 en
著者 Miwa, Takashi

× Miwa, Takashi

WEKO 74934

en Miwa, Takashi

Search repository
Kanda, Mitsuro

× Kanda, Mitsuro

WEKO 74935

en Kanda, Mitsuro

Search repository
Koike, Masahiko

× Koike, Masahiko

WEKO 74936

en Koike, Masahiko

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Iwata, Naoki

× Iwata, Naoki

WEKO 74937

en Iwata, Naoki

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Tanaka, Haruyoshi

× Tanaka, Haruyoshi

WEKO 74938

en Tanaka, Haruyoshi

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Umeda, Shinichi

× Umeda, Shinichi

WEKO 74939

en Umeda, Shinichi

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Tanaka, Chie

× Tanaka, Chie

WEKO 74940

en Tanaka, Chie

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Kobayashi, Daisuke

× Kobayashi, Daisuke

WEKO 74941

en Kobayashi, Daisuke

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Hayashi, Masamichi

× Hayashi, Masamichi

WEKO 74942

en Hayashi, Masamichi

Search repository
Yamada, Suguru

× Yamada, Suguru

WEKO 74943

en Yamada, Suguru

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Fujii, Tsutomu

× Fujii, Tsutomu

WEKO 74944

en Fujii, Tsutomu

Search repository
Fujiwara, Michitaka

× Fujiwara, Michitaka

WEKO 74945

en Fujiwara, Michitaka

Search repository
Kodera, Yasuhiro

× Kodera, Yasuhiro

WEKO 74946

en Kodera, Yasuhiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 The poor prognosis and increasing incidence of esophageal squamous cell carcinoma (ESCC) highlight the need for identification of novel ESCC‑associated molecular events to improve the diagnosis, and treatment of this disease. Non‑specific cytotoxic cell receptor protein 1 (NCCRP1) was reported to be abundantly expressed in human squamous epithelium and to be involved in cell proliferation; however, the role of NCCRP1 in ESCC remains unclear. To elucidate the oncological roles of NCCRP1 in ESCC, NCCRP1 expression, DNA methylation, and copy numbers were analyzed in ESCC cell lines. Nine ESCC cell lines demonstrated different NCCRP1 mRNA expression levels and all exhibited hypermethylation of the NCCRP1 promoter, but no copy number loss. Additionally, NCCRP1 expression was determined in 213 surgically resected esophageal tissue samples. NCCRP1 mRNA expression levels were reduced in ESCC tissues compared with corresponding non‑cancerous adjacent tissues in 204 (95.8%) patients. Patients in the low NCCRP1 expression group tended to have a higher recurrence rate and a shorter overall survival time compared with those in the high NCCRP1 expression group. Additionally, multivariate analysis revealed that low NCCRP1 expression was an independent prognostic factor (hazard ratio, 1.75; 95% confidence interval, 1.08‑2.87; P=0.022). The findings of the current study indicate that NCCRP1 acts as a putative tumor suppressor that is inactivated through promoter hypermethylation, and serves as a promising biomarker to predict postoperative prognosis in ESCC.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Spandidos Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3892/ol.2017.6753
ISSN
収録物識別子タイプ PISSN
収録物識別子 1792-1074
書誌情報 en : ONCOLOGY LETTERS

巻 14, 号 4, p. 4822-4828, 発行日 2017-10
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.3892/ol.2017.6753
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27335
識別子タイプ HDL
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