{"created":"2021-03-01T06:33:08.660360+00:00","id":25137,"links":{},"metadata":{"_buckets":{"deposit":"bc542424-7439-4bbe-a479-fec39732d401"},"_deposit":{"id":"25137","owners":[],"pid":{"revision_id":0,"type":"depid","value":"25137"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00025137","sets":["336:695:696"]},"author_link":["75012","75013","75014","75015","75016"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-29","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9062","bibliographicPageStart":"9058","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"ChemistrySelect","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inhibition self-assembly of β-amyloid (Aβ) is considered to be a strategy that can be potentially useful to develop treatment for Alzheimer's disease (AD). We have discovered that a protein unit that is found in the fimbriae of Gram-negative bacteria, which has a vacant site for a β-sheet strand, prevents Aβ oligomerization effectively. Moreover, we found that a soluble but denatured form of this protein shows even higher potency. Our results also demonstrate the applicability of denatured proteins as pharmaceutical material.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1002/slct.201700658"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/27357"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/slct.201700658","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: [K. Yamamoto, M. Oyaizu, T. Takahashi, Y. Watanabe, O. Shoji.(2017), Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria.　ChemistrySelect,2:9058–9062. doi:10.1002/slct.201700658], which has been published in final form at [http://doi.org/10.1002/slct.201700658]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2365-6549","subitem_source_identifier_type":"EISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"75012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oyaizu, Misa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"75013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"75014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Yoshihito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"75015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoji, Osami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"75016","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-29"}],"displaytype":"detail","filename":"manuscript_slct_201700658R2.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"manuscript_slct_201700658R2.pdf ファイル公開日:2018/09/29","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/25137/files/manuscript_slct_201700658R2.pdf"},"version_id":"0aad957f-430a-4c2b-87fb-184d9c89160f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["696"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-02-05"},"publish_date":"2018-02-05","publish_status":"0","recid":"25137","relation_version_is_last":true,"title":["Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:14:22.453729+00:00"}