{"_buckets": {"deposit": "fd57c12e-ca30-4f36-8109-da3cfff18d5e"}, "_deposit": {"id": "25696", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25696"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00025696", "sets": ["667"]}, "author_link": ["76094", "76095", "76096", "76097", "76098", "76099"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-12-19", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "71", "bibliographicPageEnd": "17897", "bibliographicPageStart": "17894", "bibliographicVolumeNumber": "23", "bibliographic_titles": [{"bibliographic_title": "Chemistry - A European Journal", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Cytotoxicity‐guided fractionation of the culture broth of Actinomadura sp. TP‐A0019 led to the isolation of quinocidin (1), a cytotoxic antibiotic with an unusual 3,4‐dihydroquinolizinium ring. The structural assignment was made on the basis of high‐field NMR experiments and chemical synthesis. Comparison of the spectral properties of 1 with those of its synthetic counterparts revealed that 1 is a racemic mixture of two enantiomers, which showed similar cytotoxicity against HeLa‐S3 cells. Nucleophile‐trapping experiments demonstrated that 1 captured 2‐mercaptoethanol and N‐acetyl‐l‐cysteine by means of a Michael addition‐type reaction, but was inert toward 2‐aminoethanol and glycolic acid. Notably, the addition of 1 to thiols proceeded smoothly in neutral aqueous media at room temperature. In view of the thiol‐trapping ability and the unusual structure, 1 provides a unique scaffold for designing drug leads and protein‐labeling probes.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開：2018-12-19", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/chem.201704729", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": " \t\"This is the peer reviewed version of the following article: [Y. Nakagawa, Y. Sawaki, T. Kimura, T. Tomura, Y. Igarashi, M. Ojika, Chem. Eur. J. 2017, 23, 17894.], which has been published in final form at [http://doi.org/10.1002/chem.201704729]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.\" ", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09476539", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakagawa, Yu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "76094", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawaki, Yuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "76095", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "76096", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomura, Tomohiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "76097", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Igarashi, Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "76098", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ojika, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "76099", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-12-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Manuscript_Nakagawa.pdf", "filesize": [{"value": "330.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 330100.0, "url": {"label": "Manuscript_Nakagawa", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/25696/files/Manuscript_Nakagawa.pdf"}, "version_id": "22ddf184-35f4-4df7-b640-de2711ccb6e5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "drug discovery", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Michael addition", "subitem_subject_scheme": "Other"}, {"subitem_subject": "natural products", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nitrogen heterocycles", "subitem_subject_scheme": "Other"}, {"subitem_subject": "structure elucidation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["667"], "permalink_uri": "http://hdl.handle.net/2237/00027907", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-04-16"}, "publish_date": "2018-04-16", "publish_status": "0", "recid": "25696", "relation": {}, "relation_version_is_last": true, "title": ["Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols"], "weko_shared_id": -1}