{"created":"2021-03-01T06:33:58.724140+00:00","id":26086,"links":{},"metadata":{"_buckets":{"deposit":"0ab49923-fec3-4324-885c-5e8c600228c2"},"_deposit":{"id":"26086","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26086"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026086","sets":["1935:1936:1937"]},"author_link":["78138","78139","78140","78141","78142","78143","78144","78145","78146","78147","78148","78149","78150","78151"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"305","bibliographicPageStart":"299","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Nature Chemical Biology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The phytohormone auxin indole-3-acetic acid (IAA) regulates nearly all aspects of plant growth and development. Despite substantial progress in our understanding of auxin biology, delineating specific auxin response remains a major challenge. Auxin regulates transcriptional response via its receptors, TIR1 and AFB F-box proteins. Here we report an engineered, orthogonal auxin–TIR1 receptor pair, developed through a bump-and-hole strategy, that triggers auxin signaling without interfering with endogenous auxin or TIR1/AFBs. A synthetic, convex IAA (cvxIAA) hijacked the downstream auxin signaling in vivo both at the transcriptomic level and in specific developmental contexts, only in the presence of a complementary, concave TIR1 (ccvTIR1) receptor. Harnessing the cvxIAA–ccvTIR1 system, we provide conclusive evidence for the role of the TIR1-mediated pathway in auxin-induced seedling acid growth. The cvxIAA–ccvTIR1 system serves as a powerful tool for solving outstanding questions in auxin biology and for precise manipulation of auxin-mediated processes as a controllable switch.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2018-07-22 ","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"nature","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/nchembio.2555","subitem_relation_type_select":"DOI"}}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1552-4450","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uchida, Naoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwasaki, Rie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Ryotaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimura, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Takaho A","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Seisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Hua","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nomoto, Mika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tada, Yasuomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kinoshita, Toshinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itami, Kenichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hagihara, Shinya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Torii, Keiko U","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78151","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-22"}],"displaytype":"detail","filename":"Uchida_et_al.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Uchida_et_al","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/26086/files/Uchida_et_al.pdf"},"version_id":"5bca91f5-8173-4c83-816d-d6ba9b72d1b9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["1937"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"26086","relation_version_is_last":true,"title":["Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:28:04.952724+00:00"}