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In vitro mimicking the morphology of hepatic lobule tissue based on Ca-alginate cell sheets
http://hdl.handle.net/2237/00028311
http://hdl.handle.net/2237/00028311aafd084b-f21b-4355-afd2-8b172dd9dc1b
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-21 | |||||
タイトル | ||||||
タイトル | In vitro mimicking the morphology of hepatic lobule tissue based on Ca-alginate cell sheets | |||||
言語 | en | |||||
著者 |
Liu, Zeyang
× Liu, Zeyang× Lu, Minmin× Takeuchi, Masaru× Yue, Tao× Hasegawa, Yasuhisa× Huang, Qiang× Fukuda, Toshio |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a peer-reviewed, un-copyedited version of an article accepted for publication/published in {Biomedical Materials}. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at {https://doi.org/10.1088/1748-605X/aaa4c4}. | |||||
抄録 | ||||||
内容記述 | Artificial cell sheets are commonly utilized as buiding blocks for tissue engineering. We propose a novel approach in the fabrication of Ca-alginate gel sheets, embedded with liver cells (RLC-18) in order to mimic liver lobule tissue. Ca-alginate sheets with hepatic lobule-shaped patterns were deposited onto a micro-electrode device using electrodeposition. Viability of embedded cells was ensured to exceed 80%. Cell morphology and biofunctionality were monitored during the one-week culture period and results compared with those of traditional 2D culture. In addition, we detached cell sheets from the electrode substrate and stacked them into a 3D multi-layered structure to mimic the morphology of liver lobule tissue. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019-05-01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | IOP publishing | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1088/1748-605X/aaa4c4 | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1748-605X | |||||
書誌情報 |
en : Biomedical Materials 巻 13, 号 3, p. 035004, 発行日 2018-05 |
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著者版フラグ | ||||||
値 | author |