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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Anaplastic variant of diffuse large B-cell lymphoma with hallmark cell appearance : Two cases highlighting a broad diversity in the diagnostics

http://hdl.handle.net/2237/00028346
http://hdl.handle.net/2237/00028346
669b225b-f2bd-471a-a13c-b646752fae4b
名前 / ファイル ライセンス アクション
Pathol_Int_AnaDLBCL.pdf Pathol_Int_AnaDLBCL (758.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-07-05
タイトル
タイトル Anaplastic variant of diffuse large B-cell lymphoma with hallmark cell appearance : Two cases highlighting a broad diversity in the diagnostics
言語 en
著者 Sakakibara, Ayako

× Sakakibara, Ayako

WEKO 78428

en Sakakibara, Ayako

Search repository
Kohno, Kei

× Kohno, Kei

WEKO 78429

en Kohno, Kei

Search repository
Kuroda, Naoto

× Kuroda, Naoto

WEKO 78430

en Kuroda, Naoto

Search repository
Yorita, Kenji

× Yorita, Kenji

WEKO 78431

en Yorita, Kenji

Search repository
Megahed, Nirmeen A.

× Megahed, Nirmeen A.

WEKO 78432

en Megahed, Nirmeen A.

Search repository
Eladl, Ahmed E.

× Eladl, Ahmed E.

WEKO 78433

en Eladl, Ahmed E.

Search repository
Daroontum, Teerada

× Daroontum, Teerada

WEKO 78434

en Daroontum, Teerada

Search repository
Ishikawa, Eri

× Ishikawa, Eri

WEKO 78435

en Ishikawa, Eri

Search repository
Suzuki, Yuka

× Suzuki, Yuka

WEKO 78436

en Suzuki, Yuka

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Shimada, Satoko

× Shimada, Satoko

WEKO 78437

en Shimada, Satoko

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Nakaguro, Masato

× Nakaguro, Masato

WEKO 78438

en Nakaguro, Masato

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Shimoyama, Yoshie

× Shimoyama, Yoshie

WEKO 78439

en Shimoyama, Yoshie

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Satou, Akira

× Satou, Akira

WEKO 78440

en Satou, Akira

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Kato, Seiichi

× Kato, Seiichi

WEKO 78441

en Kato, Seiichi

Search repository
Yatabe, Yasushi

× Yatabe, Yasushi

WEKO 78442

en Yatabe, Yasushi

Search repository
Asano, Naoko

× Asano, Naoko

WEKO 78443

en Asano, Naoko

Search repository
Nakamura, Shigeo

× Nakamura, Shigeo

WEKO 78444

en Nakamura, Shigeo

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Sakakibara, A. , Kohno, K. , Kuroda, N. , Yorita, K. , Megahed, N. A., Eladl, A. E., Daroontum, T. , Ishikawa, E. , Suzuki, Y. , Shimada, S. , Nakaguro, M. , Shimoyama, Y. , Satou, A. , Kato, S. , Yatabe, Y. , Asano, N. and Nakamura, S. (2018), Anaplastic variant of diffuse large B‐cell lymphoma with hallmark cell appearance: Two cases highlighting a broad diversity in the diagnostics. Pathol Int, 68: 251-255. doi:10.1111/pin.12653], which has been published in final form at [https://doi.org/10.1111/pin.12653]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
キーワード
主題Scheme Other
主題 anaplastic variant
キーワード
主題Scheme Other
主題 classic Hodgkin lymphoma
キーワード
主題Scheme Other
主題 diffuse large B‐cell lymphoma
キーワード
主題Scheme Other
主題 gray zone lymphoma
キーワード
主題Scheme Other
主題 hallmark cell
抄録
内容記述 The anaplastic variant of diffuse large B‐cell lymphoma (A‐DLBCL) is morphologically defined but remains an enigmatic disease in its clinicopathologic distinctiveness. Here, we report two cases involving Japanese women aged 59 years, both with A‐DLBCL with the hallmark cell appearance and both indistinguishable from common and giant cell‐rich patterns, respectively, of anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma. Case 1 was immunohistochemically positive for CD20, CD79a and OCT‐2 but not for the other pan–B‐cell markers, CD30 and ALK. Case 2 showed CD20 and CD30 positivity for 50% and 20% of tumor cells in addition to strong expression of p53 and MYC. Both were positive for fascin without Epstein–Barr virus association. Our cases provide additional support for the earlier reports that A‐DLBCL exhibits clinicopathologic features distinct from ordinal diffuse large B‐cell lymphoma (DLBCL), and documented its broader morphologic diversity than previously recognized. They also shed light on the unique feature of absent expression of pan–B‐cell markers except for CD20 and CD79a, suggesting that A‐DLBCL may biologically mimic a gray zone or intermediate lymphoma between DLBCL and classic Hodgkin lymphoma.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019-04-02
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/pin.12653
ISSN
収録物識別子タイプ PISSN
収録物識別子 1320-5463
書誌情報 en : Pathology International

巻 68, 号 4, p. 251-255, 発行日 2018-04
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