{"created":"2021-03-01T06:34:08.331965+00:00","id":26231,"links":{},"metadata":{"_buckets":{"deposit":"56c29291-54b7-4e43-9069-0ecbfa3d36b8"},"_deposit":{"id":"26231","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26231"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026231","sets":["499:500:501"]},"author_link":["78695","78696"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"221","bibliographicPageStart":"211","bibliographicVolumeNumber":"372","bibliographic_titles":[{"bibliographic_title":"Cell and Tissue Research","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However, neuroblastoma initiation mechanisms and even its origin are long-standing mysteries. In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. A plausible origin of enigmatic stage 4S neuroblastoma is also discussed. With regard to the initiation mechanisms, we review genetic abnormalities in neuroblastomas and their possible association to initiation mechanisms. We also summarize evidences of neuroblastoma initiation observed in genetically engineered animal models, in which epigenetic alterations were involved, including transcriptomic upregulation by N-Myc and downregulation by polycomb repressive complex 2. Finally, several in vitro experimental methods are proposed that hopefully will accelerate our comprehension of neuroblastoma initiation. Thus, this review summarizes the state-of-the-art knowledge about the mechanisms of neuroblastoma initiation, which is critical for developing new strategies to cure children with neuroblastoma.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2019/05/01 ","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00441-018-2796-z","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is a post-peer-review, pre-copyedit version of an article published in [Cell and Tissue Research]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00441-018-2796-z”.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0302-766X","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsubota, Shoma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kadomatsu, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78696","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-01"}],"displaytype":"detail","filename":"180806_merge.pdf","filesize":[{"value":"376.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"180806_merge","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/26231/files/180806_merge.pdf"},"version_id":"e1ceab03-9a5f-4a9d-8f03-a3f90f693c1d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neuroblastoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Neural crest cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Schwann cell precursors","subitem_subject_scheme":"Other"},{"subitem_subject":"Sympathoadrenal progenitors","subitem_subject_scheme":"Other"},{"subitem_subject":"MYCN","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Origin and initiation mechanisms of neuroblastoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Origin and initiation mechanisms of neuroblastoma","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-08-07"},"publish_date":"2018-08-07","publish_status":"0","recid":"26231","relation_version_is_last":true,"title":["Origin and initiation mechanisms of neuroblastoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:16:42.700082+00:00"}