@article{oai:nagoya.repo.nii.ac.jp:00026245,
 author = {Kaga, Kahori and Honda, Masaki and Adachi, Tomoki and Honjo, Masatoshi and Wahyudiono and Kanda, Hideki and Goto, Motonobu},
 journal = {The Journal of Supercritical Fluids},
 month = {Jun},
 note = {The effects of operating conditions and Z-isomer content of astaxanthin on coprecipitate formation of polyvinylpyrrolidone (PVP) and astaxanthin by solution-enhanced dispersion by supercritical fluids (SEDS) process were investigated. Using this process, nano-sized (100–200 nm) and water-soluble PVP/astaxanthin inclusion complex was successfully prepared. As the operating pressure increased from 8 to 15 MPa at a constant temperature, astaxanthin content in the coprecipitates decreased, and increasing the operating temperature from 40 to 60 °C at a constant pressure, the particle size and the astaxanthin content increased. Increasing the PVP ratio for astaxanthin in the range of 5:1 to 20:1, the particle size decreased and when 10:1 of the ratio, the astaxanthin content in the coprecipitates was the highest (60 °C, 10 MPa). Additionally, as the Z-isomer content of astaxanthin increased, the astaxanthin content decreased slightly. However, the coprecipitates rich in astaxanthin Z-isomers, which have higher bioavailability and antioxidant capacity, were obtained., ファイル公開：2020-06-01},
 pages = {44--51},
 title = {Nanoparticle formation of PVP/astaxanthin inclusion complex by solution-enhanced dispersion by supercritical fluids (SEDS): Effect of PVP and astaxanthin  Z -isomer content},
 volume = {136},
 year = {2018}
}