{"created":"2021-03-01T06:34:14.130897+00:00","id":26320,"links":{},"metadata":{"_buckets":{"deposit":"080cbb15-4abf-4ef4-a6cc-6d4183cc5e1e"},"_deposit":{"created_by":17,"id":"26320","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"26320"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026320","sets":["499:508:509:2109"]},"author_link":["84891","84892"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"307","bibliographicPageStart":"299","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Notch signaling pathway is highly conserved and essential for animal development. It is required for cell differentiation, survival, and proliferation. Regulation of Notch signaling is a crucial process for human health. Ligands initiate a signal cascade by binding to Notch receptors expressed on a neighboring cell. Notch receptors interact with ligands through their epidermal growth factor-like repeats (EGF repeats). Most EGF repeats are modified by O-glycosylation with residues such as O-linked N-acetylglucosamine (O-GlcNAc), O-fucose, and O-glucose. These O-glycan modifications are important for Notch function. Defects in O-glycosylation affect Notch-ligand interaction, trafficking of Notch receptors, and Notch stability on the cell surface. Although the roles of each modification are not fully understood, O-fucose is essential for binding of Notch receptors to their ligands. We reported an EGF domain-specific O-GlcNAc transferase (EOGT) localized in the endoplasmic reticulum. Mutations in genes encoding EOGT or NOTCH1 cause Adams-Oliver syndrome. Dysregulation of Notch signaling because of defects or mutations in Notch receptors or Notch signal-regulating proteins, such as glycosyltransferases, induce a variety of congenital disorders. In this review, we discuss O-glycosylation of Notch receptors and congenital human diseases caused by defects in O-glycans on Notch receptors.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.80.3.299","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/803.html ","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tashima, Yuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"84891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okajima, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"84892","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-28"}],"displaytype":"detail","filename":"02_Tashima.pdf","filesize":[{"value":"446.1 kB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"02_Tashima.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/26320/files/02_Tashima.pdf"},"version_id":"82ecbfe7-89cb-4136-b761-35b8f23c2ab0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Notch receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"O-glycosylation","subitem_subject_scheme":"Other"},{"subitem_subject":"epidermal growth factor-like repeat","subitem_subject_scheme":"Other"},{"subitem_subject":"EGF domain-specific O-GlcNAc transferase","subitem_subject_scheme":"Other"},{"subitem_subject":"Adams-Oliver syndrome","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Congenital diseases caused by defective O-glycosylation of Notch receptors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Congenital diseases caused by defective O-glycosylation of Notch receptors","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["2109"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-08-28"},"publish_date":"2018-08-28","publish_status":"0","recid":"26320","relation_version_is_last":true,"title":["Congenital diseases caused by defective O-glycosylation of Notch receptors"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T04:19:33.517827+00:00"}