{"created":"2021-03-01T06:34:14.558208+00:00","id":26326,"links":{},"metadata":{"_buckets":{"deposit":"f916c739-cdf2-41f9-820e-222eed75ecb0"},"_deposit":{"id":"26326","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26326"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026326"},"item_9_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"366","bibliographicPageStart":"357","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science"}]}]},"item_9_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Some patients undergo postoperative chemotherapy despite showing impaired wound healing after a major surgery. We speculated that postoperative chemotherapy further delays wound healing in these patients. This study aimed to compare the effects of doxorubicin (DXR) in ischemic skin flap and normal incisional wound models after surgery. A 2-cm incisional wound was made in group 1 rats, and saline was injected intravenously, following surgery on the same day. Incisional wound was made in group 2\u20135 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively. H-shaped double flaps were made in group 6 rats, and saline was injected intravenously, following surgery on the same day. Flaps were made in group 7\u201310 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively. On days 7, 14, 21, and 28 after surgery, the suture wounds were removed, tensile wound strengths were measured, and tissue samples were collected for histopathological evaluation. The tensile strength was significantly lower in the DXR-treated groups than in the control groups for both ischemic skin flaps and incision wounds. Additionally, the cross effect between DXR and ischemia was not significant. On pathological examination, DXR showed atrophic skin changes and degeneration of skin appendages on days 14\u201321 after the surgery in both the models. DXR decreased the wound tensile strength and caused an atrophic change in the ischemic wound.","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"\u5185\u5bb9\u8a18\u8ff0","attribute_value_mlt":[{"subitem_description":"This work was supported by JSPS Grants-in-Aid for Scientific Research (Grant Number 24592710).","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID\u767b\u9332","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.80.3.357","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine"}]},"item_9_relation_43":{"attribute_name":"\u7570\u7248\u3067\u3042\u308b","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/803.html ","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN\uff08Online\uff09","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"ISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN\uff08print\uff09","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Morishita, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"84931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toriyama, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"84932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takanari, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"84933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yagi, Shunjiro"}],"nameIdentifiers":[{"nameIdentifier":"84934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ebisawa, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"84935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hishida, Masashi"}],"nameIdentifiers":[{"nameIdentifier":"84936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Narita, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"84937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Osaga, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"84938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishida, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"84939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamei, Yuzuru"}],"nameIdentifiers":[{"nameIdentifier":"84940","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-31"}],"displaytype":"detail","filename":"08_Morishita.pdf","filesize":[{"value":"67.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"08_Morishita.pdf","url":"https://nagoya.repo.nii.ac.jp/record/26326/files/08_Morishita.pdf"},"version_id":"53f00d97-921b-4832-9590-22b3c5b580a4"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"doxorubicin","subitem_subject_scheme":"Other"},{"subitem_subject":"postoperative chemotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"wound tensile strength","subitem_subject_scheme":"Other"},{"subitem_subject":"normal incision wound","subitem_subject_scheme":"Other"},{"subitem_subject":"ischemic skin flap","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of postoperative doxorubicin administration on ischemic wound healing","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Effect of postoperative doxorubicin administration on ischemic wound healing"}]},"item_type_id":"9","owner":"1","path":["499/508/509/2109"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2018-08-31"},"publish_date":"2018-08-31","publish_status":"0","recid":"26326","relation_version_is_last":true,"title":["Effect of postoperative doxorubicin administration on ischemic wound healing"],"weko_creator_id":"1","weko_shared_id":3},"updated":"2021-03-01T11:28:10.568114+00:00"}