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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles

http://hdl.handle.net/2237/00028544
http://hdl.handle.net/2237/00028544
b93b9d63-8cac-47ee-93cb-bdd4a0bdfd93
名前 / ファイル ライセンス アクション
Authors_final_manuscript.pdf Authors_final_manuscript (6.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-10
タイトル
タイトル Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles
言語 en
著者 Nishiwaki, Hiroshi

× Nishiwaki, Hiroshi

WEKO 85146

en Nishiwaki, Hiroshi

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Ito, Mikako

× Ito, Mikako

WEKO 85147

en Ito, Mikako

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Negishi, Shuto

× Negishi, Shuto

WEKO 85148

en Negishi, Shuto

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Sobue, Sayaka

× Sobue, Sayaka

WEKO 85149

en Sobue, Sayaka

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Ichihara, Masatoshi

× Ichihara, Masatoshi

WEKO 85150

en Ichihara, Masatoshi

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Ohno, Kinji

× Ohno, Kinji

WEKO 85151

en Ohno, Kinji

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Free Radical Research on 20/03/2018, available online: http://www.tandfonline.com/10.1080/10715762.2018.1439166.
キーワード
主題Scheme Other
主題 Molecular hydrogen
キーワード
主題Scheme Other
主題 meta-analysis
キーワード
主題Scheme Other
主題 cross-platform analysis
キーワード
主題Scheme Other
主題 pathway analysis
キーワード
主題Scheme Other
主題 heat-shock protein
抄録
内容記述タイプ Abstract
内容記述 Molecular hydrogen exerts its effect on multiple pathologies, including oxidative stress, inflammation, and apoptosis. However, its molecular mechanisms have not been fully elucidated. In order to explore the effects of molecular hydrogen, we meta-analysed gene expression profiles modulated by molecular hydrogen. We performed microarray analysis of the mouse liver with or without drinking hydrogen water. We also integrated two previously reported microarray datasets of the rat liver into meta-analyses. We used two categories of meta-analysis methods: the cross-platform method and the conventional meta-analysis method (Fisher’s method). For each method, hydrogen-modulated pathways were analysed by (i) the hypergeometric test (HGT) in the class of over-representation analysis (ORA), (ii) the gene set enrichment analysis (GSEA) in the class of functional class scoring (FCS), and (iii) the signalling pathway impact analysis (SPIA), pathway regulation score (PRS), and others in the class of pathway topology-based approach (PTA). Pathways in the collagen biosynthesis and the heat-shock response were up-regulated according to (a) HGT with the cross-platform method, (b) GSEA with the cross-platform method, and (c) PRS with the cross-platform method. Pathways in cell cycles were down-regulated according to (a) HGT with the cross-platform method, (b) GSEA with the cross-platform method, and (d) GSEA with the conventional meta-analysis method. Because the heat-shock response leads to up-regulation of collagen biosynthesis and a transient arrest of cell cycles, induction of the heat-shock response is likely to be a primary event induced by molecular hydrogen in the liver of wild-type rodents.
言語 en
内容記述
内容記述タイプ Other
内容記述 ファイル公開:2019/03/20
言語 ja
出版者
出版者 Taylor & Francis
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/10715762.2018.1439166
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1071-5762
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1029-2470
書誌情報 en : Free Radical Research

巻 52, 号 4, p. 434-445, 発行日 2018-03-20
著者版フラグ
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