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Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles
http://hdl.handle.net/2237/00028544
http://hdl.handle.net/2237/00028544b93b9d63-8cac-47ee-93cb-bdd4a0bdfd93
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Authors_final_manuscript (6.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-10 | |||||
| タイトル | ||||||
| タイトル | Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles | |||||
| 言語 | en | |||||
| 著者 |
Nishiwaki, Hiroshi
× Nishiwaki, Hiroshi× Ito, Mikako× Negishi, Shuto× Sobue, Sayaka× Ichihara, Masatoshi× Ohno, Kinji |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Free Radical Research on 20/03/2018, available online: http://www.tandfonline.com/10.1080/10715762.2018.1439166. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Molecular hydrogen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | meta-analysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cross-platform analysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pathway analysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heat-shock protein | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Molecular hydrogen exerts its effect on multiple pathologies, including oxidative stress, inflammation, and apoptosis. However, its molecular mechanisms have not been fully elucidated. In order to explore the effects of molecular hydrogen, we meta-analysed gene expression profiles modulated by molecular hydrogen. We performed microarray analysis of the mouse liver with or without drinking hydrogen water. We also integrated two previously reported microarray datasets of the rat liver into meta-analyses. We used two categories of meta-analysis methods: the cross-platform method and the conventional meta-analysis method (Fisher’s method). For each method, hydrogen-modulated pathways were analysed by (i) the hypergeometric test (HGT) in the class of over-representation analysis (ORA), (ii) the gene set enrichment analysis (GSEA) in the class of functional class scoring (FCS), and (iii) the signalling pathway impact analysis (SPIA), pathway regulation score (PRS), and others in the class of pathway topology-based approach (PTA). Pathways in the collagen biosynthesis and the heat-shock response were up-regulated according to (a) HGT with the cross-platform method, (b) GSEA with the cross-platform method, and (c) PRS with the cross-platform method. Pathways in cell cycles were down-regulated according to (a) HGT with the cross-platform method, (b) GSEA with the cross-platform method, and (d) GSEA with the conventional meta-analysis method. Because the heat-shock response leads to up-regulation of collagen biosynthesis and a transient arrest of cell cycles, induction of the heat-shock response is likely to be a primary event induced by molecular hydrogen in the liver of wild-type rodents. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2019/03/20 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/10715762.2018.1439166 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1071-5762 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1029-2470 | |||||
| 書誌情報 |
en : Free Radical Research 巻 52, 号 4, p. 434-445, 発行日 2018-03-20 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
