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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin

http://hdl.handle.net/2237/00028560
http://hdl.handle.net/2237/00028560
66ff037f-1bd1-44a9-a3af-cf8b3872d2bd
名前 / ファイル ライセンス アクション
Akiyama_JDS_Revision2018.pdf Akiyama_JDS_Revision2018 (671.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-11
タイトル
タイトル Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin
言語 en
著者 Akiyama, Masashi

× Akiyama, Masashi

WEKO 85223

en Akiyama, Masashi

Search repository
Takeichi, Takuya

× Takeichi, Takuya

WEKO 85224

en Takeichi, Takuya

Search repository
McGrath, John A.

× McGrath, John A.

WEKO 85225

en McGrath, John A.

Search repository
Sugiura, Kazumitsu

× Sugiura, Kazumitsu

WEKO 85226

en Sugiura, Kazumitsu

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Autoinflammation
キーワード
主題Scheme Other
主題 CARD14
キーワード
主題Scheme Other
主題 IL-36 receptor antagonist
キーワード
主題Scheme Other
主題 Keratinization
キーワード
主題Scheme Other
主題 Keratosis lichenoides chronica
キーワード
主題Scheme Other
主題 NLRP1
キーワード
主題Scheme Other
主題 Pityriasis rubra pilaris
キーワード
主題Scheme Other
主題 Psoriasis
キーワード
主題Scheme Other
主題 Psoriatic arthritis
キーワード
主題Scheme Other
主題 Pustular psoriasis
抄録
内容記述 Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term “autoinflammatory keratinization diseases” (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Mechanistically, the entities include generalized pustular psoriasis (GPP) without psoriasis vulgaris, impetigo herpetiformis and acrodermatitis continua, which are IL-36Ra-related pustuloses caused by loss-of-function mutations in IL36RN; GPP with psoriasis vulgaris and palmoplantar pustular psoriasis which are CARD14-mediated pustular psoriasiform dermatoses with gain-of-function variants of CARD14; PRP type V which is caused by gain-of-function mutations in CARD14; and, familial KLC in which mutations in NLRP1, an inflammasome sensor protein predominantly expressed in skin, have been identified. It is likely that further inflammatory keratinization disorders will also fall within the concept of AIKD, as elucidation of novel pathogenic mechanisms of inflammatory keratinization diseases emerges. A better understanding of the pathophysiology of AIKD is likely to lead to innovative, targeted therapies that benefit patients.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019-05-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jdermsci.2018.01.012
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0923-1811
書誌情報 en : Journal of Dermatological Science

巻 90, 号 2, p. 105-111, 発行日 2018-05
著者版フラグ
値 author
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