{"created":"2021-03-01T06:34:16.909168+00:00","id":26361,"links":{},"metadata":{"_buckets":{"deposit":"60aabe3f-c579-4ef8-8793-1d0a0e5a7eeb"},"_deposit":{"id":"26361","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26361"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026361","sets":["499:500:501"]},"author_link":["85258","85259","85260","85261","85262","85263"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"361","bibliographicPageStart":"357","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Parasitology International","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hymenolepis diminuta is a parasitic tapeworm of the rat small intestine and is recognized as a useful model for the analysis of cestode-host interactions. In this study, we analyzed factors affecting the biomass of the tapeworm through use of rat strains carrying genetic mutations, namely X-linked severe combined immunodeficiency (xscid; T, B and NK cells deficiency), nude (rnu; T cell deficiency), and mast cell deficient rats. The worm biomass of F344-xscid rats after infection with 5 cysticercoids was much larger than control F344 rats from 3 to 8 weeks. The biomass of F344-rnu rats was also larger than the controls, but was intermediate between F344-xscid and control rats. These observations demonstrated that host immunity can control the maximal tapeworm biomass, i.e., carrying capacity, of the rat small intestine. Both T cell and other immune cells (B and NK cells) have roles in determining the carrying capacity of tapeworms. Total worm biomass and worm numbers in mast cell deficient rats (WsRC-Ws/Ws) were not significantly different from control WsRC-+/+ rats after 3 and 6 weeks of primary infection. Mast cell deficient rats displayed reinfection resistance for worm biomass but not worm expulsion. These findings suggest that the mast cell has a role for controlling the biomass of this tapeworm in reinfection alone, but does not affect the rate of worm expulsion. Overall, our findings indicate that the mast cell is not a major effector cell for the control of the carrying capacity of tapeworms. The identity of the major effector cell remains unknown.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2019-08-01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.parint.2018.02.003","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1383-5769","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohno, Tamio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"85258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kai, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"85259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyasaka, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"85260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Haruhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"85261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishih, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"85262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kino, Hideto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"85263","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-01"}],"displaytype":"detail","filename":"Ohno_T_H_diminuta-Revised.pdf","filesize":[{"value":"267.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ohno_T_H_diminuta-Revised","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/26361/files/Ohno_T_H_diminuta-Revised.pdf"},"version_id":"13ba5c24-44cd-41a3-b4db-bfa193ee3e22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carrying capacity","subitem_subject_scheme":"Other"},{"subitem_subject":"Hymenolepis diminuta","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune-deficient rat","subitem_subject_scheme":"Other"},{"subitem_subject":"Mast cell deficient rat","subitem_subject_scheme":"Other"},{"subitem_subject":"Worm biomass","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-09-11"},"publish_date":"2018-09-11","publish_status":"0","recid":"26361","relation_version_is_last":true,"title":["Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:16:05.497174+00:00"}