@article{oai:nagoya.repo.nii.ac.jp:00026380,
 author = {Maeda, K. and Izawa, M. and Nakajima, Y. and Jin, Q. and Hirose, T. and Nakamura, T. and Koshino, H. and Kanamaru, K. and Ohsato, S. and Kamakura, T. and Kobayashi, T. and Yoshida, M. and Kimura, M.},
 issue = {5},
 journal = {Letters in Applied Microbiology},
 month = {Nov},
 note = {Histone deacetylases (HDACs) play an important role in the regulation of chromatin structure and gene expression. We found that dark pigmentation of Magnaporthe oryzae (anamorph Pyricularia oryzae) ΔMohda1, a mutant strain in which an orthologue of the yeast HDA1 was disrupted by double cross‐over homologous recombination, was significantly stimulated in liquid culture. Analysis of metabolites in a ΔMohda1 mutant culture revealed that the accumulation of shunt products of the 1,8‐dihydroxynaphthalene melanin and ergosterol pathways were significantly enhanced compared to the wild‐type strain. Northern blot analysis of the ΔMohda1 mutant revealed transcriptional activation of three melanin genes that are dispersed throughout the genome of M. oryzae. The effect of deletion of the yeast HDA1 orthologue was also observed in Fusarium asiaticum from the Fusarium graminearum species complex; the HDF2 deletion mutant produced increased levels of nivalenol‐type trichothecenes. These results suggest that histone modification via HDA1‐type HDAC regulates the production of natural products in filamentous fungi., ファイル公開：2018-11-01},
 pages = {446--452},
 title = {Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum},
 volume = {65},
 year = {2017}
}