{"_buckets": {"deposit": "9a1e17df-0dc2-4f87-8ba2-f25b77b4a51e"}, "_deposit": {"id": "26595", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26595"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00026595"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "239", "bibliographicPageStart": "235", "bibliographicVolumeNumber": "473", "bibliographic_titles": [{"bibliographic_title": "Virchows Archiv"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for \u03b2-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. \u03b2-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of \u03b2-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear \u03b2-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from \u03b2-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2019/08/01 ", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00428-018-2370-9", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u201cThis is a post-peer-review, pre-copyedit version of an article published in [Virchows Archiv]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-018-2370-9\u201d."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0945-6317", "subitem_source_identifier_type": "ISSN"}]}, "item_10_source_id_62": {"attribute_name": "ISSN\uff08Online\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "1432-2307", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Yuka"}], "nameIdentifiers": [{"nameIdentifier": "87940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichihara, Shu"}], "nameIdentifiers": [{"nameIdentifier": "87941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawasaki, Tomonori"}], "nameIdentifiers": [{"nameIdentifier": "87942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanai, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "87943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitagawa, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "87944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimoyama, Yoshie"}], "nameIdentifiers": [{"nameIdentifier": "87945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Shigeo"}], "nameIdentifiers": [{"nameIdentifier": "87946", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakaguro, Masato"}], "nameIdentifiers": [{"nameIdentifier": "87947", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "180430submission.pdf", "filesize": [{"value": "463.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 463800.0, "url": {"label": "180430submission", "url": "https://nagoya.repo.nii.ac.jp/record/26595/files/180430submission.pdf"}, "version_id": "dd695e26-e6f0-4bbf-b895-e1316882a785"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Sinonasal glomangiopericytoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b2-catenin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CTNNB1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LEF1", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u03b2-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u03b2-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00028798", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-11-13"}, "publish_date": "2018-11-13", "publish_status": "0", "recid": "26595", "relation": {}, "relation_version_is_last": true, "title": ["\u03b2-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)"], "weko_shared_id": null}