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β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)
http://hdl.handle.net/2237/00028798
http://hdl.handle.net/2237/00028798a156461c-1af4-4122-b024-13ca1dc27788
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-11-13 | |||||
タイトル | ||||||
タイトル | β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma) | |||||
言語 | en | |||||
著者 |
Suzuki, Yuka
× Suzuki, Yuka× Ichihara, Shu× Kawasaki, Tomonori× Yanai, Hiroyuki× Kitagawa, Satoshi× Shimoyama, Yoshie× Nakamura, Shigeo× Nakaguro, Masato |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Virchows Archiv]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-018-2370-9”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sinonasal glomangiopericytoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-catenin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CTNNB1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LEF1 | |||||
抄録 | ||||||
内容記述 | Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/08/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00428-018-2370-9 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0945-6317 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1432-2307 | |||||
書誌情報 |
en : Virchows Archiv 巻 473, 号 2, p. 235-239, 発行日 2018-08 |
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著者版フラグ | ||||||
値 | author |