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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)

http://hdl.handle.net/2237/00028798
http://hdl.handle.net/2237/00028798
a156461c-1af4-4122-b024-13ca1dc27788
名前 / ファイル ライセンス アクション
180430submission.pdf 180430submission (463.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-11-13
タイトル
タイトル β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)
言語 en
著者 Suzuki, Yuka

× Suzuki, Yuka

WEKO 87940

en Suzuki, Yuka

Search repository
Ichihara, Shu

× Ichihara, Shu

WEKO 87941

en Ichihara, Shu

Search repository
Kawasaki, Tomonori

× Kawasaki, Tomonori

WEKO 87942

en Kawasaki, Tomonori

Search repository
Yanai, Hiroyuki

× Yanai, Hiroyuki

WEKO 87943

en Yanai, Hiroyuki

Search repository
Kitagawa, Satoshi

× Kitagawa, Satoshi

WEKO 87944

en Kitagawa, Satoshi

Search repository
Shimoyama, Yoshie

× Shimoyama, Yoshie

WEKO 87945

en Shimoyama, Yoshie

Search repository
Nakamura, Shigeo

× Nakamura, Shigeo

WEKO 87946

en Nakamura, Shigeo

Search repository
Nakaguro, Masato

× Nakaguro, Masato

WEKO 87947

en Nakaguro, Masato

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Virchows Archiv]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-018-2370-9”.
キーワード
主題Scheme Other
主題 Sinonasal glomangiopericytoma
キーワード
主題Scheme Other
主題 β-catenin
キーワード
主題Scheme Other
主題 CTNNB1
キーワード
主題Scheme Other
主題 LEF1
抄録
内容記述 Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/08/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00428-018-2370-9
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0945-6317
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1432-2307
書誌情報 en : Virchows Archiv

巻 473, 号 2, p. 235-239, 発行日 2018-08
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