{"created":"2021-03-01T06:34:31.568337+00:00","id":26595,"links":{},"metadata":{"_buckets":{"deposit":"9a1e17df-0dc2-4f87-8ba2-f25b77b4a51e"},"_deposit":{"id":"26595","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26595"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026595","sets":["499:500:501"]},"author_link":["87940","87941","87942","87943","87944","87945","87946","87947"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"239","bibliographicPageStart":"235","bibliographicVolumeNumber":"473","bibliographic_titles":[{"bibliographic_title":"Virchows Archiv","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2019/08/01 ","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00428-018-2370-9","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is a post-peer-review, pre-copyedit version of an article published in [Virchows Archiv]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-018-2370-9”.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0945-6317","subitem_source_identifier_type":"PISSN"}]},"item_10_source_id_62":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"1432-2307","subitem_source_identifier_type":"EISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichihara, Shu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawasaki, Tomonori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanai, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitagawa, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimoyama, Yoshie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Shigeo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakaguro, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87947","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-01"}],"displaytype":"detail","filename":"180430submission.pdf","filesize":[{"value":"463.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"180430submission","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/26595/files/180430submission.pdf"},"version_id":"dd695e26-e6f0-4bbf-b895-e1316882a785"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sinonasal glomangiopericytoma","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"CTNNB1","subitem_subject_scheme":"Other"},{"subitem_subject":"LEF1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-13"},"publish_date":"2018-11-13","publish_status":"0","recid":"26595","relation_version_is_last":true,"title":["β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:16:55.697179+00:00"}