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Manganese in toenails is associated with hearing loss at high frequencies in humans
http://hdl.handle.net/2237/00029069
http://hdl.handle.net/2237/00029069eba490a4-0fb0-45dd-92bf-6e8e1c3ddffc
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-11-14 | |||||
タイトル | ||||||
タイトル | Manganese in toenails is associated with hearing loss at high frequencies in humans | |||||
言語 | en | |||||
著者 |
Ohgami, Nobutaka
× Ohgami, Nobutaka× Li, Xiang× Yajima, Ichiro× Oshino, Reina× Ohgami, Kyoko× Kato, Yoko× Ahsan, Nazmul× Akhand, Anwarul Azim× Kato, Masashi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Biomarkers on 10/04/2018, available online: http://www.tandfonline.com/10.1080/1354750X.2018.1458153. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | manganese | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hearing loss | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | toenails | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inner ears | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ICP-MS | |||||
抄録 | ||||||
内容記述 | Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/04/10 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Taylor & Francis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1080/1354750X.2018.1458153 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1354-750X | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1366-5804 | |||||
書誌情報 |
en : Biomarkers 巻 23, 号 6, p. 533-539, 発行日 2018-04-10 |
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著者版フラグ | ||||||
値 | author |