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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Manganese in toenails is associated with hearing loss at high frequencies in humans

http://hdl.handle.net/2237/00029069
http://hdl.handle.net/2237/00029069
eba490a4-0fb0-45dd-92bf-6e8e1c3ddffc
名前 / ファイル ライセンス アクション
Ohgami_re-revised_manuscript.pdf Ohgami_re-revised_manuscript (319.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-11-14
タイトル
タイトル Manganese in toenails is associated with hearing loss at high frequencies in humans
言語 en
著者 Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 87973

en Ohgami, Nobutaka

Search repository
Li, Xiang

× Li, Xiang

WEKO 87974

en Li, Xiang

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Yajima, Ichiro

× Yajima, Ichiro

WEKO 87975

en Yajima, Ichiro

Search repository
Oshino, Reina

× Oshino, Reina

WEKO 87976

en Oshino, Reina

Search repository
Ohgami, Kyoko

× Ohgami, Kyoko

WEKO 87977

en Ohgami, Kyoko

Search repository
Kato, Yoko

× Kato, Yoko

WEKO 87978

en Kato, Yoko

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Ahsan, Nazmul

× Ahsan, Nazmul

WEKO 87979

en Ahsan, Nazmul

Search repository
Akhand, Anwarul Azim

× Akhand, Anwarul Azim

WEKO 87980

en Akhand, Anwarul Azim

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 87981

en Kato, Masashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Biomarkers on 10/04/2018, available online: http://www.tandfonline.com/10.1080/1354750X.2018.1458153.
キーワード
主題Scheme Other
主題 manganese
キーワード
主題Scheme Other
主題 hearing loss
キーワード
主題Scheme Other
主題 toenails
キーワード
主題Scheme Other
主題 inner ears
キーワード
主題Scheme Other
主題 ICP-MS
抄録
内容記述 Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/04/10
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/1354750X.2018.1458153
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1354-750X
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1366-5804
書誌情報 en : Biomarkers

巻 23, 号 6, p. 533-539, 発行日 2018-04-10
著者版フラグ
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