{"_buckets": {"deposit": "cac60cac-1dec-4ab1-94e0-8d5e13bd54cc"}, "_deposit": {"id": "26866", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26866"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00026866"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-04-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "539", "bibliographicPageStart": "533", "bibliographicVolumeNumber": "23", "bibliographic_titles": [{"bibliographic_title": "Biomarkers"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8\u2009kHz and 12\u2009kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2019/04/10", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Taylor \u0026 Francis"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1080/1354750X.2018.1458153", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is an Accepted Manuscript of an article published by Taylor \u0026 Francis Group in Biomarkers on 10/04/2018, available online: http://www.tandfonline.com/10.1080/1354750X.2018.1458153."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "1354-750X", "subitem_source_identifier_type": "ISSN"}]}, "item_10_source_id_62": {"attribute_name": "ISSN\uff08Online\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "1366-5804", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohgami, Nobutaka"}], "nameIdentifiers": [{"nameIdentifier": "87973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Xiang"}], "nameIdentifiers": [{"nameIdentifier": "87974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yajima, Ichiro"}], "nameIdentifiers": [{"nameIdentifier": "87975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshino, Reina"}], "nameIdentifiers": [{"nameIdentifier": "87976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohgami, Kyoko"}], "nameIdentifiers": [{"nameIdentifier": "87977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "87978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ahsan, Nazmul"}], "nameIdentifiers": [{"nameIdentifier": "87979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akhand, Anwarul Azim"}], "nameIdentifiers": [{"nameIdentifier": "87980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "87981", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-04-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Ohgami_re-revised_manuscript.pdf", "filesize": [{"value": "319.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 319300.0, "url": {"label": "Ohgami_re-revised_manuscript", "url": "https://nagoya.repo.nii.ac.jp/record/26866/files/Ohgami_re-revised_manuscript.pdf"}, "version_id": "3932f6f9-7889-41a1-9646-bcbb002cb571"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "manganese", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hearing loss", "subitem_subject_scheme": "Other"}, {"subitem_subject": "toenails", "subitem_subject_scheme": "Other"}, {"subitem_subject": "inner ears", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ICP-MS", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Manganese in toenails is associated with hearing loss at high frequencies in humans", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Manganese in toenails is associated with hearing loss at high frequencies in humans"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00029069", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-11-14"}, "publish_date": "2018-11-14", "publish_status": "0", "recid": "26866", "relation": {}, "relation_version_is_last": true, "title": ["Manganese in toenails is associated with hearing loss at high frequencies in humans"], "weko_shared_id": null}