{"created":"2021-03-01T06:34:49.368340+00:00","id":26866,"links":{},"metadata":{"_buckets":{"deposit":"cac60cac-1dec-4ab1-94e0-8d5e13bd54cc"},"_deposit":{"id":"26866","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26866"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00026866","sets":["499:500:501"]},"author_link":["87973","87974","87975","87976","87977","87978","87979","87980","87981"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"539","bibliographicPageStart":"533","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Biomarkers","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2019/04/10","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/1354750X.2018.1458153","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Accepted Manuscript of an article published by Taylor & Francis Group in Biomarkers on 10/04/2018, available online: http://www.tandfonline.com/10.1080/1354750X.2018.1458153.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1354-750X","subitem_source_identifier_type":"PISSN"}]},"item_10_source_id_62":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"1366-5804","subitem_source_identifier_type":"EISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohgami, Nobutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Xiang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yajima, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshino, Reina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohgami, Kyoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ahsan, Nazmul","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akhand, Anwarul Azim","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"87981","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-10"}],"displaytype":"detail","filename":"Ohgami_re-revised_manuscript.pdf","filesize":[{"value":"319.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ohgami_re-revised_manuscript","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/26866/files/Ohgami_re-revised_manuscript.pdf"},"version_id":"3932f6f9-7889-41a1-9646-bcbb002cb571"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"manganese","subitem_subject_scheme":"Other"},{"subitem_subject":"hearing loss","subitem_subject_scheme":"Other"},{"subitem_subject":"toenails","subitem_subject_scheme":"Other"},{"subitem_subject":"inner ears","subitem_subject_scheme":"Other"},{"subitem_subject":"ICP-MS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Manganese in toenails is associated with hearing loss at high frequencies in humans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Manganese in toenails is associated with hearing loss at high frequencies in humans","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-14"},"publish_date":"2018-11-14","publish_status":"0","recid":"26866","relation_version_is_last":true,"title":["Manganese in toenails is associated with hearing loss at high frequencies in humans"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:43:43.785610+00:00"}