@article{oai:nagoya.repo.nii.ac.jp:00026928,
 author = {La Penna, Giovanni and Mori, Yoshiharu and Kitahara, Ryo and Akasaka, Kazuyuki and Okamoto, Yuko},
 issue = {8},
 journal = {The Journal of Chemical Physics},
 month = {Aug},
 note = {Nitrogen chemical shift is a useful parameter for determining the backbone three-dimensional structure of proteins. Empirical models for fast calculation of N chemical shift are improving their reliability, but there are subtle effects that cannot be easily interpreted. Among these, the effects of slight changes in hydrogen bonds, both intramolecular and with water molecules in the solvent, are particularly difficult to predict. On the other hand, these hydrogen bonds are sensitive to changes in protein environment. In this work, the change of N chemical shift with pressure for backbone segments in the protein ubiquitin is correlated with the change in the population of hydrogen bonds involving the backbone amide group. The different extent of interaction of protein backbone with the water molecules in the solvent is put in evidence.},
 title = {Modeling 15N NMR chemical shift changes in protein backbone with pressure},
 volume = {145},
 year = {2016}
}