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NEW CONFORMATIONAL SEARCH METHOD USING GENETIC ALGORITHM AND KNOT THEORY FOR PROTEINS
http://hdl.handle.net/2237/00029168
http://hdl.handle.net/2237/00029168b52e5868-b069-456b-8de7-049783a24bc0
名前 / ファイル | ライセンス | アクション |
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Item type | 図書の一部 / Book Chapter(1) | |||||
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公開日 | 2018-12-27 | |||||
タイトル | ||||||
タイトル | NEW CONFORMATIONAL SEARCH METHOD USING GENETIC ALGORITHM AND KNOT THEORY FOR PROTEINS | |||||
言語 | en | |||||
著者 |
SAKAE, Y.
× SAKAE, Y.× HIROYASU, T.× MIKI, M.× OKAMOTO, Y. |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | CC-BY-NC | |||||
抄録 | ||||||
内容記述 | We have proposed a parallel simulated annealing using genetic crossover as one of powerful conformational search methods, in order to find the global minimum energy structures for protein systems. The simulated annealing using genetic crossover method, which incorporates the attractive features of the simulated annealing and the genetic algorithm, is useful for finding a minimum potential energy conformation of protein systems. However, when we perform simulations by using this method, we often find obviously unnatural stable conformations, which have "knots" of a string of an amino-acid sequence. Therefore, we combined knot theory with our simulated annealing using genetic crossover method in order to avoid the knot conformations from the conformational search space. We applied this improved method to protein G, which has 56 amino acids. As the result, we could perform the simulations, which avoid knot conformations. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | World Scientific | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_3248 | |||||
タイプ | book part | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1142/9789814335058_0023 | |||||
ISBN | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ISBN | |||||
関連識別子 | 978-981-4335-05-8 | |||||
図書名 | ||||||
図書名 | Biocomputing 2011 | |||||
書誌情報 |
p. 217-228, 発行日 2010-11 |
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著者版フラグ | ||||||
値 | publisher |