@article{oai:nagoya.repo.nii.ac.jp:00027179, author = {Wang, Lyu-Ming and Jenkinson, Kellie and Wheatley, Andrew E. H. and Kuwata, Keiko and Saito, Susumu and Naka, Hiroshi}, issue = {11}, journal = {ACS Sustainable Chemistry & Engineering}, month = {Nov}, note = {Amines in heteroaromatic systems and pharmaceutical intermediates were functionalized through N-methylation with methanol using a palladium-loaded titanium dioxide (Pd/TiO2) photocatalyst. This method provides access to a series of tertiary N-methylamines bearing N-, O-, and/or S-containing heteroaromatic functionalities from primary/secondary amines and methanol under mild reaction conditions. Facile syntheses of several pharmaceuticals containing N-methyl or ethyl groups, as well as related deuterated drugs, was achieved through the late-stage functionalization of amines., ファイル公開:2019-11-05}, pages = {15419--15424}, title = {Photocatalytic N-Methylation of Amines over Pd/TiO2 for the Functionalization of Heterocycles and Pharmaceutical Intermediates}, volume = {6}, year = {2018} }