{"_buckets": {"deposit": "c62619b8-0bd1-4a45-8b48-83329a7a61a7"}, "_deposit": {"id": "27931", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "27931"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00027931"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "91", "bibliographicPageStart": "83", "bibliographicVolumeNumber": "98", "bibliographic_titles": [{"bibliographic_title": "Annals of Hematology"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We analyzed the clinical significance and genetic features of ASXL2 and ZBTB7A mutations, and the alternatively spliced isoform of the RUNX1-RUNX1T1 transcript, which is also called AML1-ETO9a (AE9a), in Japanese CBF-AML patients enrolled in the JALSG AML201 study. ASXL2 and ZBTB7A genes were sequenced using bone marrow samples of 41 AML patients with t(8;21) and 14 with inv(16). The relative expression levels of AE9a were quantified using the real-time PCR assay in 23 AML patients with t(8;21). We identified ASXL2 (34.1%) and ZBTB7A (9.8%) mutations in only AML patients with t(8;21). ASXL2-mutated patients had a significantly higher WBC count at diagnosis (P\u2009=\u20090.04) and a lower frequency of sex chromosome loss than wild-type patients (33 vs. 76%, respectively, P\u2009=\u20090.01). KIT mutations were the most frequently accompanied with both ASXL2 (36%) and ZBTB7A (75%) mutations. Neither ASXL2 nor ZBTB7A mutations had an impact on overall or event-free survival. Patients harboring cohesin complex gene mutations expressed significantly higher levels of AE9a than unmutated patients (P\u2009=\u20090.03). In conclusion, ASXL2 and ZBTB7A mutations were frequently identified in Japanese AML patients with t(8;21), but not in those with inv(16). Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2020/01/01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00277-018-3492-5", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u201cThis is a post-peer-review, pre-copyedit version of an article published in [Annals of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00277-018-3492-5\u201d."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0939-5555", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawashima, Naomi"}], "nameIdentifiers": [{"nameIdentifier": "90925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akashi, Akimi"}], "nameIdentifiers": [{"nameIdentifier": "90926", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagata, Yasunobu"}], "nameIdentifiers": [{"nameIdentifier": "90927", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kihara, Rika"}], "nameIdentifiers": [{"nameIdentifier": "90928", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Yuichi"}], "nameIdentifiers": [{"nameIdentifier": "90929", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asou, Norio"}], "nameIdentifiers": [{"nameIdentifier": "90930", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohtake, Shigeki"}], "nameIdentifiers": [{"nameIdentifier": "90931", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyawaki, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "90932", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakura, Toru"}], "nameIdentifiers": [{"nameIdentifier": "90933", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozawa, Yukiyasu"}], "nameIdentifiers": [{"nameIdentifier": "90934", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usui, Noriko"}], "nameIdentifiers": [{"nameIdentifier": "90935", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanamori, Heiwa"}], "nameIdentifiers": [{"nameIdentifier": "90936", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Yoshikazu"}], "nameIdentifiers": [{"nameIdentifier": "90937", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imai, Kiyotoshi"}], "nameIdentifiers": [{"nameIdentifier": "90938", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suehiro, Youko"}], "nameIdentifiers": [{"nameIdentifier": "90939", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Kunio"}], "nameIdentifiers": [{"nameIdentifier": "90940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakaida, Emiko"}], "nameIdentifiers": [{"nameIdentifier": "90941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeshita, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "90942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzushima, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "90943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naoe, Tomoki"}], "nameIdentifiers": [{"nameIdentifier": "90944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumura, Itaru"}], "nameIdentifiers": [{"nameIdentifier": "90945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "90946", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Seishi"}], "nameIdentifiers": [{"nameIdentifier": "90947", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyoi, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "90948", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Ann_Hematol_Kawashima_et_al.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "Ann_Hematol_Kawashima_et_al", "url": "https://nagoya.repo.nii.ac.jp/record/27931/files/Ann_Hematol_Kawashima_et_al.pdf"}, "version_id": "70b54ea3-d539-40b3-9124-015b05dae623"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Acute myeloid leukemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Core-binding factor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ASXL1/2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ZBTB7A", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RUNX1-RUX1T1 transcript", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00030130", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-05-08"}, "publish_date": "2019-05-08", "publish_status": "0", "recid": "27931", "relation": {}, "relation_version_is_last": true, "title": ["Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study"], "weko_shared_id": null}