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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study

http://hdl.handle.net/2237/00030130
http://hdl.handle.net/2237/00030130
c6c1aa48-b2d6-42a2-a84e-eef46e0aa1c2
名前 / ファイル ライセンス アクション
Ann_Hematol_Kawashima_et_al.pdf Ann_Hematol_Kawashima_et_al (1.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-05-08
タイトル
タイトル Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study
言語 en
著者 Kawashima, Naomi

× Kawashima, Naomi

WEKO 90925

en Kawashima, Naomi

Search repository
Akashi, Akimi

× Akashi, Akimi

WEKO 90926

en Akashi, Akimi

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Nagata, Yasunobu

× Nagata, Yasunobu

WEKO 90927

en Nagata, Yasunobu

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Kihara, Rika

× Kihara, Rika

WEKO 90928

en Kihara, Rika

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Ishikawa, Yuichi

× Ishikawa, Yuichi

WEKO 90929

en Ishikawa, Yuichi

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Asou, Norio

× Asou, Norio

WEKO 90930

en Asou, Norio

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Ohtake, Shigeki

× Ohtake, Shigeki

WEKO 90931

en Ohtake, Shigeki

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Miyawaki, Shuichi

× Miyawaki, Shuichi

WEKO 90932

en Miyawaki, Shuichi

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Sakura, Toru

× Sakura, Toru

WEKO 90933

en Sakura, Toru

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Ozawa, Yukiyasu

× Ozawa, Yukiyasu

WEKO 90934

en Ozawa, Yukiyasu

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Usui, Noriko

× Usui, Noriko

WEKO 90935

en Usui, Noriko

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Kanamori, Heiwa

× Kanamori, Heiwa

WEKO 90936

en Kanamori, Heiwa

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Ito, Yoshikazu

× Ito, Yoshikazu

WEKO 90937

en Ito, Yoshikazu

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Imai, Kiyotoshi

× Imai, Kiyotoshi

WEKO 90938

en Imai, Kiyotoshi

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Suehiro, Youko

× Suehiro, Youko

WEKO 90939

en Suehiro, Youko

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Kitamura, Kunio

× Kitamura, Kunio

WEKO 90940

en Kitamura, Kunio

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Sakaida, Emiko

× Sakaida, Emiko

WEKO 90941

en Sakaida, Emiko

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Takeshita, Akihiro

× Takeshita, Akihiro

WEKO 90942

en Takeshita, Akihiro

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Suzushima, Hitoshi

× Suzushima, Hitoshi

WEKO 90943

en Suzushima, Hitoshi

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Naoe, Tomoki

× Naoe, Tomoki

WEKO 90944

en Naoe, Tomoki

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Matsumura, Itaru

× Matsumura, Itaru

WEKO 90945

en Matsumura, Itaru

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Miyazaki, Yasushi

× Miyazaki, Yasushi

WEKO 90946

en Miyazaki, Yasushi

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Ogawa, Seishi

× Ogawa, Seishi

WEKO 90947

en Ogawa, Seishi

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Kiyoi, Hitoshi

× Kiyoi, Hitoshi

WEKO 90948

en Kiyoi, Hitoshi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Annals of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00277-018-3492-5”.
キーワード
主題Scheme Other
主題 Acute myeloid leukemia
キーワード
主題Scheme Other
主題 Core-binding factor
キーワード
主題Scheme Other
主題 ASXL1/2
キーワード
主題Scheme Other
主題 ZBTB7A
キーワード
主題Scheme Other
主題 RUNX1-RUX1T1 transcript
抄録
内容記述 We analyzed the clinical significance and genetic features of ASXL2 and ZBTB7A mutations, and the alternatively spliced isoform of the RUNX1-RUNX1T1 transcript, which is also called AML1-ETO9a (AE9a), in Japanese CBF-AML patients enrolled in the JALSG AML201 study. ASXL2 and ZBTB7A genes were sequenced using bone marrow samples of 41 AML patients with t(8;21) and 14 with inv(16). The relative expression levels of AE9a were quantified using the real-time PCR assay in 23 AML patients with t(8;21). We identified ASXL2 (34.1%) and ZBTB7A (9.8%) mutations in only AML patients with t(8;21). ASXL2-mutated patients had a significantly higher WBC count at diagnosis (P = 0.04) and a lower frequency of sex chromosome loss than wild-type patients (33 vs. 76%, respectively, P = 0.01). KIT mutations were the most frequently accompanied with both ASXL2 (36%) and ZBTB7A (75%) mutations. Neither ASXL2 nor ZBTB7A mutations had an impact on overall or event-free survival. Patients harboring cohesin complex gene mutations expressed significantly higher levels of AE9a than unmutated patients (P = 0.03). In conclusion, ASXL2 and ZBTB7A mutations were frequently identified in Japanese AML patients with t(8;21), but not in those with inv(16). Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020/01/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00277-018-3492-5
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0939-5555
書誌情報 en : Annals of Hematology

巻 98, 号 1, p. 83-91, 発行日 2019-01
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