{"created":"2021-03-01T06:35:58.121478+00:00","id":27931,"links":{},"metadata":{"_buckets":{"deposit":"c62619b8-0bd1-4a45-8b48-83329a7a61a7"},"_deposit":{"id":"27931","owners":[],"pid":{"revision_id":0,"type":"depid","value":"27931"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00027931"},"item_10_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"91","bibliographicPageStart":"83","bibliographicVolumeNumber":"98","bibliographic_titles":[{"bibliographic_title":"Annals of Hematology"}]}]},"item_10_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"We analyzed the clinical significance and genetic features of ASXL2 and ZBTB7A mutations, and the alternatively spliced isoform of the RUNX1-RUNX1T1 transcript, which is also called AML1-ETO9a (AE9a), in Japanese CBF-AML patients enrolled in the JALSG AML201 study. ASXL2 and ZBTB7A genes were sequenced using bone marrow samples of 41 AML patients with t(8;21) and 14 with inv(16). The relative expression levels of AE9a were quantified using the real-time PCR assay in 23 AML patients with t(8;21). We identified ASXL2 (34.1%) and ZBTB7A (9.8%) mutations in only AML patients with t(8;21). ASXL2-mutated patients had a significantly higher WBC count at diagnosis (P\u2009=\u20090.04) and a lower frequency of sex chromosome loss than wild-type patients (33 vs. 76%, respectively, P\u2009=\u20090.01). KIT mutations were the most frequently accompanied with both ASXL2 (36%) and ZBTB7A (75%) mutations. Neither ASXL2 nor ZBTB7A mutations had an impact on overall or event-free survival. Patients harboring cohesin complex gene mutations expressed significantly higher levels of AE9a than unmutated patients (P\u2009=\u20090.03). In conclusion, ASXL2 and ZBTB7A mutations were frequently identified in Japanese AML patients with t(8;21), but not in those with inv(16). Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex.","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"\u5185\u5bb9\u8a18\u8ff0","attribute_value_mlt":[{"subitem_description":"\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2020/01/01","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00277-018-3492-5","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"\u6a29\u5229","attribute_value_mlt":[{"subitem_rights":"\u201cThis is a post-peer-review, pre-copyedit version of an article published in [Annals of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00277-018-3492-5\u201d."}]},"item_10_select_15":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN\uff08print\uff09","attribute_value_mlt":[{"subitem_source_identifier":"0939-5555","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawashima, Naomi"}],"nameIdentifiers":[{"nameIdentifier":"90925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akashi, Akimi"}],"nameIdentifiers":[{"nameIdentifier":"90926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Yasunobu"}],"nameIdentifiers":[{"nameIdentifier":"90927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kihara, Rika"}],"nameIdentifiers":[{"nameIdentifier":"90928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"90929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asou, Norio"}],"nameIdentifiers":[{"nameIdentifier":"90930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohtake, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"90931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyawaki, Shuichi"}],"nameIdentifiers":[{"nameIdentifier":"90932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakura, Toru"}],"nameIdentifiers":[{"nameIdentifier":"90933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Yukiyasu"}],"nameIdentifiers":[{"nameIdentifier":"90934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usui, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"90935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanamori, Heiwa"}],"nameIdentifiers":[{"nameIdentifier":"90936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"90937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Kiyotoshi"}],"nameIdentifiers":[{"nameIdentifier":"90938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suehiro, Youko"}],"nameIdentifiers":[{"nameIdentifier":"90939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Kunio"}],"nameIdentifiers":[{"nameIdentifier":"90940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakaida, Emiko"}],"nameIdentifiers":[{"nameIdentifier":"90941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeshita, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"90942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzushima, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"90943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoe, Tomoki"}],"nameIdentifiers":[{"nameIdentifier":"90944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumura, Itaru"}],"nameIdentifiers":[{"nameIdentifier":"90945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"90946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Seishi"}],"nameIdentifiers":[{"nameIdentifier":"90947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyoi, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"90948","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-01"}],"displaytype":"detail","filename":"Ann_Hematol_Kawashima_et_al.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ann_Hematol_Kawashima_et_al","url":"https://nagoya.repo.nii.ac.jp/record/27931/files/Ann_Hematol_Kawashima_et_al.pdf"},"version_id":"70b54ea3-d539-40b3-9124-015b05dae623"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Acute myeloid leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Core-binding factor","subitem_subject_scheme":"Other"},{"subitem_subject":"ASXL1/2","subitem_subject_scheme":"Other"},{"subitem_subject":"ZBTB7A","subitem_subject_scheme":"Other"},{"subitem_subject":"RUNX1-RUX1T1 transcript","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study"}]},"item_type_id":"10","owner":"1","path":["499/500/501"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"27931","relation_version_is_last":true,"title":["Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T10:29:28.164208+00:00"}