@article{oai:nagoya.repo.nii.ac.jp:00027947,
 author = {Kanda, Tomoya and Naraoka, Asuka and Naka, Hiroshi},
 issue = {2},
 journal = {Journal of the American Chemical Society},
 month = {Jan},
 note = {We report the palladium(II)-catalyzed transfer hydration of cyanohydrins to α-hydroxyamides by using carboxamides as water donors. This method enables selective hydration of various aldehyde- and ketone-derived cyanohydrins to afford α-mono- and α,α-disubstituted-α-hydroxyamides, respectively, under mild conditions (50 °C, 10 min). The direct conversion of fenofibrate, a drug bearing a benzophenone moiety, into a functionalized α,α-diaryl-α-hydroxyamide was achieved by means of a hydrocyanation–transfer hydration sequence. Preliminary kinetic studies and the synthesis of a site-specifically 18O-labeled α-hydroxyamide demonstrated the carbonyl oxygen transfer from the carboxamide reagent into the α-hydroxyamide product., ファイル公開：2020-01-16},
 pages = {825--830},
 title = {Catalytic Transfer Hydration of Cyanohydrins to α-Hydroxyamides},
 volume = {141},
 year = {2019}
}