@article{oai:nagoya.repo.nii.ac.jp:00027961, author = {Uraguchi, Daisuke and Kuwata, Keiko and Hijikata, Yuh and Yamaguchi, Rie and Imaizumi, Hanae and AM, Sathiyanarayanan and Rakers, Christin and Mori, Narumi and Akiyama, Kohki and Irle, Stephan and McCourt, Peter and Kinoshita, Toshinori and Ooi, Takashi and Tsuchiya, Yuichiro}, issue = {6420}, journal = {Science}, month = {Dec}, note = {The parasitic plant Striga hermonthica has been causing devastating damage to the crop production in Africa. Because Striga requires host-generated strigolactones to germinate, the identification of selective and potent strigolactone agonists could help control these noxious weeds. We developed a selective agonist, sphynolactone-7, a hybrid molecule originated from chemical screening, that contains two functional modules derived from a synthetic scaffold and a core component of strigolactones. Cooperative action of these modules in the activation of a high-affinity strigolactone receptor ShHTL7 allows sphynolactone-7 to provoke Striga germination with potency in the femtomolar range. We demonstrate that sphynolactone-7 is effective for reducing Striga parasitism without impinging on host strigolactone-related processes.}, pages = {1301--1305}, title = {A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica}, volume = {362}, year = {2018} }