{"created":"2021-03-01T06:36:00.620916+00:00","id":27969,"links":{},"metadata":{"_buckets":{"deposit":"2305aca8-7f4c-4e13-8a42-edf3736f8d7d"},"_deposit":{"id":"27969","owners":[],"pid":{"revision_id":0,"type":"depid","value":"27969"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00027969","sets":["499:500:501"]},"author_link":["91120","91121","91122","91123","91124","91125","91126","91127","91128","91129","91130","91131","91132"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"192","bibliographicPageStart":"181","bibliographicVolumeNumber":"442","bibliographic_titles":[{"bibliographic_title":"Cancer Letters","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The mesothelium, covered by a continuous monolayer of mesothelial cells, is the first protective barrier against metastatic ovarian cancer. However, mesothelial cells release tumor-promoting factors that accelerate the process of peritoneal metastasis. We identified cancer-associated mesothelial cells (CAMs) that had tumor-promoting potential. Here, we found that plasminogen activator inhibitor-1 (PAI-1) induced the formation of CAMs, after which CAMs increasingly secreted the oncogenic factors interleukin-8 (IL-8) and C-X-C motif chemokine ligand 5 (CXCL5), further promoting the metastasis of ovarian cancer cells in a feedback loop. After the formation of CAMs, PAI-1 activated the nuclear factor kappa B (NFκB) pathway in the CAMs, thus transcriptionally upregulating the expression of the downstream NFκB targets IL-8 and CXCL5. Moreover, PAI-1 correlated with peritoneal metastasis in ovarian cancer patients and indicated a poor prognosis. In both ex vivo and in vivo models, after PAI-1 expression was knocked down, the metastasis of ovarian cancer cells decreased significantly. Therefore, targeting PAI-1 may provide a potential target for future therapeutics to prevent the formation of CAMs and alleviate peritoneal metastasis in ovarian cancer patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2020-02-01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.canlet.2018.10.027","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0304-3835","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Peng, Yang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kajiyama, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuan, Hong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Kae","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshihara, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoi, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujikake, Kayo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91126","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasui, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshikawa, Nobuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91128","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Shiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91129","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Senga, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91130","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Kiyosumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91131","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikkawa, Fumitaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91132","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-01"}],"displaytype":"detail","filename":"20190509original_file_of_paper.pdf","filesize":[{"value":"9.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20190509original_file_of_paper","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/27969/files/20190509original_file_of_paper.pdf"},"version_id":"dedc0d48-1efc-4ae4-afbd-f8cd628e5749"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ovarian cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer-associated mesothelial cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasminogen activator inhibitor-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Peritoneal metastasis","subitem_subject_scheme":"Other"},{"subitem_subject":"Microenvironment","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-10"},"publish_date":"2019-05-10","publish_status":"0","recid":"27969","relation_version_is_last":true,"title":["PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:20:13.724713+00:00"}