WEKO3
アイテム
{"_buckets": {"deposit": "d04c3018-503f-4dae-8a97-e81139451bd0"}, "_deposit": {"id": "27971", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "27971"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00027971", "sets": ["501"]}, "author_link": ["91135", "91136", "91137", "91138", "91139", "91140", "91141", "91142", "91143", "91144", "91145", "91146", "91147"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "607", "bibliographicPageStart": "597", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "Clinical and Experimental Nephrology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: The mortality and morbidity associated with acute kidney injury (AKI) remains high, despite advances in interventions. A multifunctional heparin-binding growth factor, midkine (MK), is involved in the pathogenesis of ischemic kidney injury. However, the clinical relevance of MK has not yet been elucidated. The present study investigated whether urinary MK can serve as a novel biomarker of AKI. Methods: We initially compared the predictive value of MK with other urinary biomarkers, including N-acetyl-β-d-glucosaminidase (NAG), interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin (NGAL), for the detection and differential diagnosis of established AKI (549 patients). Subsequently, the reliability of MK for the early detection of AKI was prospectively evaluated in 40 patients undergoing elective abdominal aortic aneurysm surgery. Urine samples were obtained at baseline, the period of aortic cross-clamping and declamping, the end of the surgery, and on post-operative day 1. Results: The areas under the receiver operating characteristic curves for the diagnosis of AKI in various kidney diseases were 0.88, 0.70, 0.72, and 0.84 for MK, NAG, IL-18, and NGAL, respectively. When the optimal cutoff value of urinary MK was set at 11.5 pg/mL, the sensitivity and specificity were 0.87 and 0.85, respectively. In the second study, urinary MK peaked at the period of aortic declamping, about 1 h after cross-clamping in patients with AKI. Interestingly, the rise of MK in AKI patients was very precipitous compared with other biomarker candidates. Conclusion: Urinary MK was prominent in its ability to detect AKI and may allow the start of preemptive medication.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "First Online: 16 August 2016", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s10157-016-1318-0", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "“This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-016-1318-0”.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "1342-1751", "subitem_source_identifier_type": "PISSN"}]}, "item_10_source_id_62": {"attribute_name": "ISSN(Online)", "attribute_value_mlt": [{"subitem_source_identifier": "1437-7799", "subitem_source_identifier_type": "EISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashi, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Waichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91136", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kosugi, Tomoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91137", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimura, Kunihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91138", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiyama, Daisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91139", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asano, Naoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91140", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikematsu, Shinya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91141", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komori, Kimihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91142", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishiwaki, Kimitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91143", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kadomatsu, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91144", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Seiichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91145", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Shoichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91146", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuzawa, Yukio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "91147", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-05-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Hayashi_CEN_21_4_597-607.pdf", "filesize": [{"value": "177.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 177900.0, "url": {"label": "Hayashi_CEN_21_4_597-607", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/27971/files/Hayashi_CEN_21_4_597-607.pdf"}, "version_id": "eb41f69a-d0f0-45e0-9dc6-0261d6f01469"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Midkine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Acute kidney injury", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Acute tubular necrosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Biomarker", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Efficacy of urinary midkine as a biomarker in patients with acute kidney injury", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Efficacy of urinary midkine as a biomarker in patients with acute kidney injury", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00030169", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-05-10"}, "publish_date": "2019-05-10", "publish_status": "0", "recid": "27971", "relation": {}, "relation_version_is_last": true, "title": ["Efficacy of urinary midkine as a biomarker in patients with acute kidney injury"], "weko_shared_id": -1}
Efficacy of urinary midkine as a biomarker in patients with acute kidney injury
http://hdl.handle.net/2237/00030169
http://hdl.handle.net/2237/0003016989343f79-5de2-4818-a158-d77225a8c8d6
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-05-10 | |||||
タイトル | ||||||
タイトル | Efficacy of urinary midkine as a biomarker in patients with acute kidney injury | |||||
言語 | en | |||||
著者 |
Hayashi, Hiroki
× Hayashi, Hiroki× Sato, Waichi× Kosugi, Tomoki× Nishimura, Kunihiro× Sugiyama, Daisuke× Asano, Naoko× Ikematsu, Shinya× Komori, Kimihiro× Nishiwaki, Kimitoshi× Kadomatsu, Kenji× Matsuo, Seiichi× Maruyama, Shoichi× Yuzawa, Yukio |
|||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-016-1318-0”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Midkine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute kidney injury | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute tubular necrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
抄録 | ||||||
内容記述 | Background: The mortality and morbidity associated with acute kidney injury (AKI) remains high, despite advances in interventions. A multifunctional heparin-binding growth factor, midkine (MK), is involved in the pathogenesis of ischemic kidney injury. However, the clinical relevance of MK has not yet been elucidated. The present study investigated whether urinary MK can serve as a novel biomarker of AKI. Methods: We initially compared the predictive value of MK with other urinary biomarkers, including N-acetyl-β-d-glucosaminidase (NAG), interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin (NGAL), for the detection and differential diagnosis of established AKI (549 patients). Subsequently, the reliability of MK for the early detection of AKI was prospectively evaluated in 40 patients undergoing elective abdominal aortic aneurysm surgery. Urine samples were obtained at baseline, the period of aortic cross-clamping and declamping, the end of the surgery, and on post-operative day 1. Results: The areas under the receiver operating characteristic curves for the diagnosis of AKI in various kidney diseases were 0.88, 0.70, 0.72, and 0.84 for MK, NAG, IL-18, and NGAL, respectively. When the optimal cutoff value of urinary MK was set at 11.5 pg/mL, the sensitivity and specificity were 0.87 and 0.85, respectively. In the second study, urinary MK peaked at the period of aortic declamping, about 1 h after cross-clamping in patients with AKI. Interestingly, the rise of MK in AKI patients was very precipitous compared with other biomarker candidates. Conclusion: Urinary MK was prominent in its ability to detect AKI and may allow the start of preemptive medication. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | First Online: 16 August 2016 | |||||
言語 | en | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10157-016-1318-0 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1342-1751 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1437-7799 | |||||
書誌情報 |
en : Clinical and Experimental Nephrology 巻 21, 号 4, p. 597-607, 発行日 2017-08 |
|||||
著者版フラグ | ||||||
値 | author |