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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Efficacy of urinary midkine as a biomarker in patients with acute kidney injury

http://hdl.handle.net/2237/00030169
http://hdl.handle.net/2237/00030169
89343f79-5de2-4818-a158-d77225a8c8d6
名前 / ファイル ライセンス アクション
Hayashi_CEN_21_4_597-607.pdf Hayashi_CEN_21_4_597-607 (177.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-05-10
タイトル
タイトル Efficacy of urinary midkine as a biomarker in patients with acute kidney injury
言語 en
著者 Hayashi, Hiroki

× Hayashi, Hiroki

WEKO 91135

en Hayashi, Hiroki

Search repository
Sato, Waichi

× Sato, Waichi

WEKO 91136

en Sato, Waichi

Search repository
Kosugi, Tomoki

× Kosugi, Tomoki

WEKO 91137

en Kosugi, Tomoki

Search repository
Nishimura, Kunihiro

× Nishimura, Kunihiro

WEKO 91138

en Nishimura, Kunihiro

Search repository
Sugiyama, Daisuke

× Sugiyama, Daisuke

WEKO 91139

en Sugiyama, Daisuke

Search repository
Asano, Naoko

× Asano, Naoko

WEKO 91140

en Asano, Naoko

Search repository
Ikematsu, Shinya

× Ikematsu, Shinya

WEKO 91141

en Ikematsu, Shinya

Search repository
Komori, Kimihiro

× Komori, Kimihiro

WEKO 91142

en Komori, Kimihiro

Search repository
Nishiwaki, Kimitoshi

× Nishiwaki, Kimitoshi

WEKO 91143

en Nishiwaki, Kimitoshi

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 91144

en Kadomatsu, Kenji

Search repository
Matsuo, Seiichi

× Matsuo, Seiichi

WEKO 91145

en Matsuo, Seiichi

Search repository
Maruyama, Shoichi

× Maruyama, Shoichi

WEKO 91146

en Maruyama, Shoichi

Search repository
Yuzawa, Yukio

× Yuzawa, Yukio

WEKO 91147

en Yuzawa, Yukio

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-016-1318-0”.
キーワード
主題Scheme Other
主題 Midkine
キーワード
主題Scheme Other
主題 Acute kidney injury
キーワード
主題Scheme Other
主題 Acute tubular necrosis
キーワード
主題Scheme Other
主題 Biomarker
抄録
内容記述 Background: The mortality and morbidity associated with acute kidney injury (AKI) remains high, despite advances in interventions. A multifunctional heparin-binding growth factor, midkine (MK), is involved in the pathogenesis of ischemic kidney injury. However, the clinical relevance of MK has not yet been elucidated. The present study investigated whether urinary MK can serve as a novel biomarker of AKI. Methods: We initially compared the predictive value of MK with other urinary biomarkers, including N-acetyl-β-d-glucosaminidase (NAG), interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin (NGAL), for the detection and differential diagnosis of established AKI (549 patients). Subsequently, the reliability of MK for the early detection of AKI was prospectively evaluated in 40 patients undergoing elective abdominal aortic aneurysm surgery. Urine samples were obtained at baseline, the period of aortic cross-clamping and declamping, the end of the surgery, and on post-operative day 1. Results: The areas under the receiver operating characteristic curves for the diagnosis of AKI in various kidney diseases were 0.88, 0.70, 0.72, and 0.84 for MK, NAG, IL-18, and NGAL, respectively. When the optimal cutoff value of urinary MK was set at 11.5 pg/mL, the sensitivity and specificity were 0.87 and 0.85, respectively. In the second study, urinary MK peaked at the period of aortic declamping, about 1 h after cross-clamping in patients with AKI. Interestingly, the rise of MK in AKI patients was very precipitous compared with other biomarker candidates. Conclusion: Urinary MK was prominent in its ability to detect AKI and may allow the start of preemptive medication.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 First Online: 16 August 2016
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10157-016-1318-0
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1342-1751
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1437-7799
書誌情報 en : Clinical and Experimental Nephrology

巻 21, 号 4, p. 597-607, 発行日 2017-08
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