{"created":"2021-03-01T06:36:03.174935+00:00","id":28007,"links":{},"metadata":{"_buckets":{"deposit":"89ae59a8-7925-457e-96bd-b47fac3acdc8"},"_deposit":{"id":"28007","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28007"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028007","sets":["499:500:501"]},"author_link":["91208","91209","91210","91211","91212","91213","91214","91215","91216","91217","91218","91219"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"214","bibliographicPageStart":"207","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Nephrology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Recent reports have described the efficacy of rituximab in treating steroid-dependent nephrotic syndrome (SDNS) in pediatric patients. However, few reports describe data regarding adult-onset SDNS. We investigated the efficacy of rituximab for the management of adult-onset SDNS. Methods: We performed a retrospective cohort study investigating eight patients with adult-onset SDNS who were treated with rituximab. Clinical data were obtained at the initiation of rituximab therapy. The primary outcomes evaluated were successful suppression of relapses and CD19+ cells after rituximab treatment. The corticosteroid- and immunosuppressant-sparing effect and adverse events were additionally evaluated. Results: All eight patients were diagnosed with minimal change nephrotic syndrome and received immunosuppressants in addition to corticosteroid. Total number of relapses was 10.5 times as a median value. Rituximab administration was repeated in two patients, whereas six received single-dose rituximab. Three of eight (37.5%) patients showed relapse after rituximab therapy. A rituximab-induced depletion in CD19+ cells noted initially was followed by their reappearance in all patients. There were cases with no relapse after the reappearance of CD19+ cells. The median relapse time pre- and post-rituximab therapy showed a decrease from 1 time/year (interquartile range [IQR] 1–3 times/year) to 0 time/year (IQR 0–1 time/year). Rituximab treatment induced a significant reduction in the required doses of corticosteroid and cyclosporine (P < 0.01). No serious adverse events were observed. Conclusion: Rituximab treatment was effective not only in childhood-onset but also in adult-onset SDNS. Further studies are needed to establish optimal treatment regimens.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2020/02/01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-018-1630-y","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-018-1630-y”.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1342-1751","subitem_source_identifier_type":"PISSN"}]},"item_10_source_id_62":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"1437-7799","subitem_source_identifier_type":"EISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Katsuno, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masuda, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Shoji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Noritoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishimoto, Takuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Sawako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kosugi, Tomoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuboi, Naotake","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuzuki, Toyonori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Yasuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91218","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Shoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91219","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-01"}],"displaytype":"detail","filename":"Therapeutic_Efficacy.pdf","filesize":[{"value":"269.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Therapeutic_Efficacy","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28007/files/Therapeutic_Efficacy.pdf"},"version_id":"0e45fda6-43a0-446a-a386-c4f05d348668"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult-onset","subitem_subject_scheme":"Other"},{"subitem_subject":"Steroid-dependent nephrotic syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Frequently relapsing nephrotic syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Minimal change nephrotic syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Rituximab","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-13"},"publish_date":"2019-05-13","publish_status":"0","recid":"28007","relation_version_is_last":true,"title":["Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:43:45.288297+00:00"}