{"created":"2021-03-01T06:36:21.619221+00:00","id":28287,"links":{},"metadata":{"_buckets":{"deposit":"6fb87c36-16d1-4dfc-adff-9051460cb847"},"_deposit":{"id":"28287","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28287"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028287","sets":["499:500:501"]},"author_link":["92256","92257","92258","92259","92260","92261","92262","92263","92264"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"213","bibliographicPageStart":"207","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"International Journal of Rheumatic Diseases","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: This study aimed to determine the influence of methotrexate (MTX) on gastrointestinal (GI) symptoms in patients with rheumatoid arthritis (RA). Methods: This cross‐sectional study examined 529 consecutive patients with RA receiving oral MTX in our department between April 1 and September 30, 2017. GI symptoms were evaluated by the Gastrointestinal Symptom Rating Scale (GSRS); a score of ≥2 was considered “symptomatic.” Prevalence of GI symptoms was compared between patients receiving ≤8 mg/wk (low‐dose) vs >8 mg/wk (high‐dose) of MTX. Results: Of our study population, 313 (59%) received low‐dose MTX at a median (interquartile range) dose of 6 (6‐8) mg/wk, whereas 216 (41%) received high‐dose MTX at a median dose of 12 (10‐12) mg/wk. Relative to the low‐dose MTX group, the high‐dose MTX group exhibited a higher prevalence of reflux (32% vs 24%, P = 0.043) and abdominal pain (28% vs 18%, P = 0.007). There was no significant group‐dependent difference in the prevalence of indigestion, diarrhea or constipation. Multivariate logistic regression analysis revealed that high‐dose MTX (>8 mg/wk) was independently associated with reflux (odds ratio [OR]: 1.62, 95% confidence interval [CI]: 1.07‐2.43) and abdominal pain (OR: 1.60, 95% CI: 1.04‐2.43), and that the ORs for reflux and abdominal pain among those receiving high‐dose MTX (>8 mg/wk) were similar to those using nonsteroidal anti‐inflammatory drugs. Conclusion: High‐dose MTX is independently associated with the prevalence of upper GI symptoms in Japanese patients with RA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2020-02-01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/1756-185X.13380","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: [Asai, S, Nagai, K, Takahashi, N, et al. Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis. Int J Rheum Dis. 2019; 22: 207– 213. https://doi.org/10.1111/apl.13380], which has been published in final form at [https://doi.org/10.1111/1756-185X.13380]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1756-1841","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asai, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Nobunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asai, Nobuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sobue, Yasumori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiguro, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Toshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92264","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-01"}],"displaytype":"detail","filename":"IJRD_R1_Manuscript_clean_180718.pdf","filesize":[{"value":"201.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJRD_R1_Manuscript_clean_180718","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28287/files/IJRD_R1_Manuscript_clean_180718.pdf"},"version_id":"47f9517d-4508-4ed9-9151-8aa1f14ed84b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gastrointestinal symptoms","subitem_subject_scheme":"Other"},{"subitem_subject":"methotrexate","subitem_subject_scheme":"Other"},{"subitem_subject":"patient‐reported outcomes","subitem_subject_scheme":"Other"},{"subitem_subject":"quality of life","subitem_subject_scheme":"Other"},{"subitem_subject":"rheumatoid arthritis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-06-24"},"publish_date":"2019-06-24","publish_status":"0","recid":"28287","relation_version_is_last":true,"title":["Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:20:51.228861+00:00"}