ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "db6a8c16-1629-48ef-9171-6e2427ffc191"}, "_deposit": {"id": "28288", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28288"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028288", "sets": ["501"]}, "author_link": ["92266", "92267", "92268", "92269", "92270", "92271", "92272", "92273", "92274", "92275", "92276", "92277", "92278", "92279", "92280", "92281", "92282", "92283", "92284", "92285", "92286"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "226", "bibliographicPageStart": "221", "bibliographicVolumeNumber": "28", "bibliographic_titles": [{"bibliographic_title": "Modern Rheumatology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: This study aimed to investigate predictors of biologic discontinuation due to insufficient response as a surrogate for relapse in patients with rheumatoid arthritis (RA) who achieved clinical remission with biologic treatment. Methods: This study was performed based on data from a multicenter registry, and included 404 patients who achieved clinical remission within the first year of treatment with their first biologic. Cumulative retention rate of the first biologic was estimated using Kaplan–Meier curves, and the impact of patient characteristics on biologic discontinuation was assessed with Cox proportional hazards models. Results: During follow-up, 50 patients discontinued their first biologic due to insufficient response. Overall discontinuation rates due to insufficient response after achieving remission were 6%, 11%, and 19% at 1, 2, and 5 years, respectively. Multivariate analysis revealed that concomitant glucocorticoids at achieving remission [hazard ratio (HR): 3.80, 95% confidence interval (CI): 1.89–7.64)] and a higher level of C-reactive protein (CRP) at achieving remission (HR: 1.47 per 1 mg/dL, 95% CI: 1.09–1.99) independently predict discontinuation due to insufficient response after achieving remission. Conclusion: Patients with RA who achieved remission with concomitant glucocorticoid treatment and a higher level of CRP are at high risk of subsequent biologic discontinuation due to insufficient response.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Published online: 13 Jul 2017", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Taylor \u0026 Francis", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1080/14397595.2017.1332558", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is an Accepted Manuscript of an article published by Taylor \u0026 Francis Group in Modern Rheumatology on 13/07/2017, available online: http://www.tandfonline.com/10.1080/14397595.2017.1332558.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "1439-7595", "subitem_source_identifier_type": "PISSN"}]}, "item_10_source_id_62": {"attribute_name": "ISSN(Online)", "attribute_value_mlt": [{"subitem_source_identifier": "1439-7609", "subitem_source_identifier_type": "EISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Asai, Shuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92266", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujibayashi, Takayoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92267", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oguchi, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92268", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanabayashi, Masahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92269", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Masatoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92270", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsubara, Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92271", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Takayasu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92272", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yabe, Yuichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92273", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Tsuyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Yuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanayama, Yasuhide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneko, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Takefumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takagi, Hideki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Nobunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Funahashi, Koji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92281", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takemoto, Toki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asai, Nobuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92283", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Tatsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92284", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiguro, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92285", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kojima, Toshihisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92286", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "relapse_MR_Manuscript_R2_clean_final.pdf", "filesize": [{"value": "158.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 158500.0, "url": {"label": "relapse_MR_Manuscript_R2_clean_final", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/28288/files/relapse_MR_Manuscript_R2_clean_final.pdf"}, "version_id": "6efaaab0-02da-4dee-a73f-51f7037c20c5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Biologics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glucocorticoids", "subitem_subject_scheme": "Other"}, {"subitem_subject": "relapse", "subitem_subject_scheme": "Other"}, {"subitem_subject": "remission", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rheumatoid arthritis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00030484", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-24"}, "publish_date": "2019-06-24", "publish_status": "0", "recid": "28288", "relation": {}, "relation_version_is_last": true, "title": ["Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study

http://hdl.handle.net/2237/00030484
http://hdl.handle.net/2237/00030484
5f66e049-d25c-44ab-9ab5-5d095a16a835
名前 / ファイル ライセンス アクション
relapse_MR_Manuscript_R2_clean_final.pdf relapse_MR_Manuscript_R2_clean_final (158.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-24
タイトル
タイトル Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study
言語 en
著者 Asai, Shuji

× Asai, Shuji

WEKO 92266

en Asai, Shuji

Search repository
Fujibayashi, Takayoshi

× Fujibayashi, Takayoshi

WEKO 92267

en Fujibayashi, Takayoshi

Search repository
Oguchi, Takeshi

× Oguchi, Takeshi

WEKO 92268

en Oguchi, Takeshi

Search repository
Hanabayashi, Masahiro

× Hanabayashi, Masahiro

WEKO 92269

en Hanabayashi, Masahiro

Search repository
Hayashi, Masatoshi

× Hayashi, Masatoshi

WEKO 92270

en Hayashi, Masatoshi

Search repository
Matsubara, Hiroyuki

× Matsubara, Hiroyuki

WEKO 92271

en Matsubara, Hiroyuki

Search repository
Ito, Takayasu

× Ito, Takayasu

WEKO 92272

en Ito, Takayasu

Search repository
Yabe, Yuichiro

× Yabe, Yuichiro

WEKO 92273

en Yabe, Yuichiro

Search repository
Watanabe, Tsuyoshi

× Watanabe, Tsuyoshi

WEKO 92274

en Watanabe, Tsuyoshi

Search repository
Hirano, Yuji

× Hirano, Yuji

WEKO 92275

en Hirano, Yuji

Search repository
Kanayama, Yasuhide

× Kanayama, Yasuhide

WEKO 92276

en Kanayama, Yasuhide

Search repository
Kaneko, Atsushi

× Kaneko, Atsushi

WEKO 92277

en Kaneko, Atsushi

Search repository
Kato, Takefumi

× Kato, Takefumi

WEKO 92278

en Kato, Takefumi

Search repository
Takagi, Hideki

× Takagi, Hideki

WEKO 92279

en Takagi, Hideki

Search repository
Takahashi, Nobunori

× Takahashi, Nobunori

WEKO 92280

en Takahashi, Nobunori

Search repository
Funahashi, Koji

× Funahashi, Koji

WEKO 92281

en Funahashi, Koji

Search repository
Takemoto, Toki

× Takemoto, Toki

WEKO 92282

en Takemoto, Toki

Search repository
Asai, Nobuyuki

× Asai, Nobuyuki

WEKO 92283

en Asai, Nobuyuki

Search repository
Watanabe, Tatsuo

× Watanabe, Tatsuo

WEKO 92284

en Watanabe, Tatsuo

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 92285

en Ishiguro, Naoki

Search repository
Kojima, Toshihisa

× Kojima, Toshihisa

WEKO 92286

en Kojima, Toshihisa

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Modern Rheumatology on 13/07/2017, available online: http://www.tandfonline.com/10.1080/14397595.2017.1332558.
キーワード
主題Scheme Other
主題 Biologics
キーワード
主題Scheme Other
主題 glucocorticoids
キーワード
主題Scheme Other
主題 relapse
キーワード
主題Scheme Other
主題 remission
キーワード
主題Scheme Other
主題 rheumatoid arthritis
抄録
内容記述 Objective: This study aimed to investigate predictors of biologic discontinuation due to insufficient response as a surrogate for relapse in patients with rheumatoid arthritis (RA) who achieved clinical remission with biologic treatment. Methods: This study was performed based on data from a multicenter registry, and included 404 patients who achieved clinical remission within the first year of treatment with their first biologic. Cumulative retention rate of the first biologic was estimated using Kaplan–Meier curves, and the impact of patient characteristics on biologic discontinuation was assessed with Cox proportional hazards models. Results: During follow-up, 50 patients discontinued their first biologic due to insufficient response. Overall discontinuation rates due to insufficient response after achieving remission were 6%, 11%, and 19% at 1, 2, and 5 years, respectively. Multivariate analysis revealed that concomitant glucocorticoids at achieving remission [hazard ratio (HR): 3.80, 95% confidence interval (CI): 1.89–7.64)] and a higher level of C-reactive protein (CRP) at achieving remission (HR: 1.47 per 1 mg/dL, 95% CI: 1.09–1.99) independently predict discontinuation due to insufficient response after achieving remission. Conclusion: Patients with RA who achieved remission with concomitant glucocorticoid treatment and a higher level of CRP are at high risk of subsequent biologic discontinuation due to insufficient response.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 Published online: 13 Jul 2017
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/14397595.2017.1332558
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1439-7595
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1439-7609
書誌情報 en : Modern Rheumatology

巻 28, 号 2, p. 221-226, 発行日 2018
著者版フラグ
値 author
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 10:14:31.686915
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3