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Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study
http://hdl.handle.net/2237/00030484
http://hdl.handle.net/2237/000304845f66e049-d25c-44ab-9ab5-5d095a16a835
名前 / ファイル | ライセンス | アクション |
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relapse_MR_Manuscript_R2_clean_final (158.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-24 | |||||
タイトル | ||||||
タイトル | Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study | |||||
言語 | en | |||||
著者 |
Asai, Shuji
× Asai, Shuji× Fujibayashi, Takayoshi× Oguchi, Takeshi× Hanabayashi, Masahiro× Hayashi, Masatoshi× Matsubara, Hiroyuki× Ito, Takayasu× Yabe, Yuichiro× Watanabe, Tsuyoshi× Hirano, Yuji× Kanayama, Yasuhide× Kaneko, Atsushi× Kato, Takefumi× Takagi, Hideki× Takahashi, Nobunori× Funahashi, Koji× Takemoto, Toki× Asai, Nobuyuki× Watanabe, Tatsuo× Ishiguro, Naoki× Kojima, Toshihisa |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Modern Rheumatology on 13/07/2017, available online: http://www.tandfonline.com/10.1080/14397595.2017.1332558. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biologics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glucocorticoids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | relapse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | remission | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rheumatoid arthritis | |||||
抄録 | ||||||
内容記述 | Objective: This study aimed to investigate predictors of biologic discontinuation due to insufficient response as a surrogate for relapse in patients with rheumatoid arthritis (RA) who achieved clinical remission with biologic treatment. Methods: This study was performed based on data from a multicenter registry, and included 404 patients who achieved clinical remission within the first year of treatment with their first biologic. Cumulative retention rate of the first biologic was estimated using Kaplan–Meier curves, and the impact of patient characteristics on biologic discontinuation was assessed with Cox proportional hazards models. Results: During follow-up, 50 patients discontinued their first biologic due to insufficient response. Overall discontinuation rates due to insufficient response after achieving remission were 6%, 11%, and 19% at 1, 2, and 5 years, respectively. Multivariate analysis revealed that concomitant glucocorticoids at achieving remission [hazard ratio (HR): 3.80, 95% confidence interval (CI): 1.89–7.64)] and a higher level of C-reactive protein (CRP) at achieving remission (HR: 1.47 per 1 mg/dL, 95% CI: 1.09–1.99) independently predict discontinuation due to insufficient response after achieving remission. Conclusion: Patients with RA who achieved remission with concomitant glucocorticoid treatment and a higher level of CRP are at high risk of subsequent biologic discontinuation due to insufficient response. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | Published online: 13 Jul 2017 | |||||
言語 | en | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Taylor & Francis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1080/14397595.2017.1332558 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1439-7595 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1439-7609 | |||||
書誌情報 |
en : Modern Rheumatology 巻 28, 号 2, p. 221-226, 発行日 2018 |
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著者版フラグ | ||||||
値 | author |