{"created":"2021-03-01T06:36:21.686507+00:00","id":28288,"links":{},"metadata":{"_buckets":{"deposit":"db6a8c16-1629-48ef-9171-6e2427ffc191"},"_deposit":{"id":"28288","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28288"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028288","sets":["499:500:501"]},"author_link":["92266","92267","92268","92269","92270","92271","92272","92273","92274","92275","92276","92277","92278","92279","92280","92281","92282","92283","92284","92285","92286"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"226","bibliographicPageStart":"221","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Modern Rheumatology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: This study aimed to investigate predictors of biologic discontinuation due to insufficient response as a surrogate for relapse in patients with rheumatoid arthritis (RA) who achieved clinical remission with biologic treatment. Methods: This study was performed based on data from a multicenter registry, and included 404 patients who achieved clinical remission within the first year of treatment with their first biologic. Cumulative retention rate of the first biologic was estimated using Kaplan–Meier curves, and the impact of patient characteristics on biologic discontinuation was assessed with Cox proportional hazards models. Results: During follow-up, 50 patients discontinued their first biologic due to insufficient response. Overall discontinuation rates due to insufficient response after achieving remission were 6%, 11%, and 19% at 1, 2, and 5 years, respectively. Multivariate analysis revealed that concomitant glucocorticoids at achieving remission [hazard ratio (HR): 3.80, 95% confidence interval (CI): 1.89–7.64)] and a higher level of C-reactive protein (CRP) at achieving remission (HR: 1.47 per 1 mg/dL, 95% CI: 1.09–1.99) independently predict discontinuation due to insufficient response after achieving remission. Conclusion: Patients with RA who achieved remission with concomitant glucocorticoid treatment and a higher level of CRP are at high risk of subsequent biologic discontinuation due to insufficient response.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Published online: 13 Jul 2017","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/14397595.2017.1332558","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Accepted Manuscript of an article published by Taylor & Francis Group in Modern Rheumatology on 13/07/2017, available online: http://www.tandfonline.com/10.1080/14397595.2017.1332558.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1439-7595","subitem_source_identifier_type":"PISSN"}]},"item_10_source_id_62":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"1439-7609","subitem_source_identifier_type":"EISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asai, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujibayashi, Takayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oguchi, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanabayashi, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Masatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsubara, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Takayasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yabe, Yuichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanayama, Yasuhide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaneko, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Takefumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagi, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Nobunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Funahashi, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takemoto, Toki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asai, Nobuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiguro, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Toshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92286","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-24"}],"displaytype":"detail","filename":"relapse_MR_Manuscript_R2_clean_final.pdf","filesize":[{"value":"158.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"relapse_MR_Manuscript_R2_clean_final","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28288/files/relapse_MR_Manuscript_R2_clean_final.pdf"},"version_id":"6efaaab0-02da-4dee-a73f-51f7037c20c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biologics","subitem_subject_scheme":"Other"},{"subitem_subject":"glucocorticoids","subitem_subject_scheme":"Other"},{"subitem_subject":"relapse","subitem_subject_scheme":"Other"},{"subitem_subject":"remission","subitem_subject_scheme":"Other"},{"subitem_subject":"rheumatoid arthritis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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multicenter observational cohort study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:20:51.579607+00:00"}