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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Cancer-associated fibroblasts in gastrointestinal cancer

http://hdl.handle.net/2237/00030590
http://hdl.handle.net/2237/00030590
959ff230-f754-41ee-97f0-8868522899e7
名前 / ファイル ライセンス アクション
Kobayashi Kobayashi et al_Final version_cleaned_by_AE (456.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-08-09
タイトル
タイトル Cancer-associated fibroblasts in gastrointestinal cancer
言語 en
著者 Kobayashi, Hiroki

× Kobayashi, Hiroki

WEKO 92915

en Kobayashi, Hiroki

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Enomoto, Atsushi

× Enomoto, Atsushi

WEKO 92916

en Enomoto, Atsushi

Search repository
Woods, Susan L.

× Woods, Susan L.

WEKO 92917

en Woods, Susan L.

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Burt, Alastair D.

× Burt, Alastair D.

WEKO 92918

en Burt, Alastair D.

Search repository
Takahashi, Masahide

× Takahashi, Masahide

WEKO 92919

en Takahashi, Masahide

Search repository
Worthley, Daniel L.

× Worthley, Daniel L.

WEKO 92920

en Worthley, Daniel L.

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme, includes fibroblasts, immune cells, blood vessels and the extracellular matrix and substantially influences the initiation, growth and dissemination of gastrointestinal cancer. Cancer-associated fibroblasts (CAFs) are one of the critical components of the tumour mesenchyme and not only provide physical support for epithelial cells but also are key functional regulators in cancer, promoting and retarding tumorigenesis in a context-dependent manner. In this Review, we outline the emerging understanding of gastrointestinal CAFs with a particular emphasis on their origin and heterogeneity, as well as their function in cancer cell proliferation, tumour immunity, angiogenesis, extracellular matrix remodelling and drug resistance. Moreover, we discuss the clinical implications of CAFs as biomarkers and potential targets for prevention and treatment of patients with gastrointestinal cancer.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019-11-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Nature
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41575-019-0115-0
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1759-5045
書誌情報 en : Nature Reviews Gastroenterology & Hepatology

巻 16, 号 5, p. 282-295, 発行日 2019-05
著者版フラグ
値 author
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