WEKO3
アイテム
{"_buckets": {"deposit": "d18b36a2-26b8-4464-b7b6-18d0add7bc95"}, "_deposit": {"id": "28397", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28397"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028397", "sets": ["501"]}, "author_link": ["92915", "92916", "92917", "92918", "92919", "92920"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "295", "bibliographicPageStart": "282", "bibliographicVolumeNumber": "16", "bibliographic_titles": [{"bibliographic_title": "Nature Reviews Gastroenterology \u0026 Hepatology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme, includes fibroblasts, immune cells, blood vessels and the extracellular matrix and substantially influences the initiation, growth and dissemination of gastrointestinal cancer. Cancer-associated fibroblasts (CAFs) are one of the critical components of the tumour mesenchyme and not only provide physical support for epithelial cells but also are key functional regulators in cancer, promoting and retarding tumorigenesis in a context-dependent manner. In this Review, we outline the emerging understanding of gastrointestinal CAFs with a particular emphasis on their origin and heterogeneity, as well as their function in cancer cell proliferation, tumour immunity, angiogenesis, extracellular matrix remodelling and drug resistance. Moreover, we discuss the clinical implications of CAFs as biomarkers and potential targets for prevention and treatment of patients with gastrointestinal cancer.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開:2019-11-01", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41575-019-0115-0", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "1759-5045", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kobayashi, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92915", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Enomoto, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92916", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Woods, Susan L.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92917", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Burt, Alastair D.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92918", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Masahide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Worthley, Daniel L.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92920", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-11-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Kobayashi et al_Final version_cleaned_by_AE.pdf", "filesize": [{"value": "456.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 456800.0, "url": {"label": "Kobayashi et al_Final version_cleaned_by_AE", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/28397/files/Kobayashi et al_Final version_cleaned_by_AE.pdf"}, "version_id": "9fe05846-e4a7-4877-8b70-80b65a3c1fe0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cancer-associated fibroblasts in gastrointestinal cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cancer-associated fibroblasts in gastrointestinal cancer", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00030590", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-08-09"}, "publish_date": "2019-08-09", "publish_status": "0", "recid": "28397", "relation": {}, "relation_version_is_last": true, "title": ["Cancer-associated fibroblasts in gastrointestinal cancer"], "weko_shared_id": -1}
Cancer-associated fibroblasts in gastrointestinal cancer
http://hdl.handle.net/2237/00030590
http://hdl.handle.net/2237/00030590959ff230-f754-41ee-97f0-8868522899e7
名前 / ファイル | ライセンス | アクション |
---|---|---|
Kobayashi et al_Final version_cleaned_by_AE (456.8 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-08-09 | |||||
タイトル | ||||||
タイトル | Cancer-associated fibroblasts in gastrointestinal cancer | |||||
言語 | en | |||||
著者 |
Kobayashi, Hiroki
× Kobayashi, Hiroki× Enomoto, Atsushi× Woods, Susan L.× Burt, Alastair D.× Takahashi, Masahide× Worthley, Daniel L. |
|||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme, includes fibroblasts, immune cells, blood vessels and the extracellular matrix and substantially influences the initiation, growth and dissemination of gastrointestinal cancer. Cancer-associated fibroblasts (CAFs) are one of the critical components of the tumour mesenchyme and not only provide physical support for epithelial cells but also are key functional regulators in cancer, promoting and retarding tumorigenesis in a context-dependent manner. In this Review, we outline the emerging understanding of gastrointestinal CAFs with a particular emphasis on their origin and heterogeneity, as well as their function in cancer cell proliferation, tumour immunity, angiogenesis, extracellular matrix remodelling and drug resistance. Moreover, we discuss the clinical implications of CAFs as biomarkers and potential targets for prevention and treatment of patients with gastrointestinal cancer. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019-11-01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nature | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41575-019-0115-0 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1759-5045 | |||||
書誌情報 |
en : Nature Reviews Gastroenterology & Hepatology 巻 16, 号 5, p. 282-295, 発行日 2019-05 |
|||||
著者版フラグ | ||||||
値 | author |