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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

A Novel Laparoscopic Surgery Model with a Device to Expand the Abdominal Working Space in Rats: The Influence of Pneumoperitoneum and Skin Incision Length on Postoperative Inflammatory Cytokines

http://hdl.handle.net/2237/00030592
http://hdl.handle.net/2237/00030592
dac54a49-46b5-4878-bc86-07572f7ddba2
名前 / ファイル ライセンス アクション
A_novel_laparoscopic_surgery_model.pdf A_novel_laparoscopic_surgery_model (707.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-08-09
タイトル
タイトル A Novel Laparoscopic Surgery Model with a Device to Expand the Abdominal Working Space in Rats: The Influence of Pneumoperitoneum and Skin Incision Length on Postoperative Inflammatory Cytokines
言語 en
著者 Murase, Naruhiko

× Murase, Naruhiko

WEKO 92924

en Murase, Naruhiko

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Tainaka, Takahisa

× Tainaka, Takahisa

WEKO 92925

en Tainaka, Takahisa

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Uchida, Hiroo

× Uchida, Hiroo

WEKO 92926

en Uchida, Hiroo

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Hinoki, Akinari

× Hinoki, Akinari

WEKO 92927

en Hinoki, Akinari

Search repository
Shirota, Chiyoe

× Shirota, Chiyoe

WEKO 92928

en Shirota, Chiyoe

Search repository
Yokota, Kazuki

× Yokota, Kazuki

WEKO 92929

en Yokota, Kazuki

Search repository
Oshima, Kazuo

× Oshima, Kazuo

WEKO 92930

en Oshima, Kazuo

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Shirotsuki, Ryo

× Shirotsuki, Ryo

WEKO 92931

en Shirotsuki, Ryo

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Chiba, Kosuke

× Chiba, Kosuke

WEKO 92932

en Chiba, Kosuke

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Tanaka, Yujiro

× Tanaka, Yujiro

WEKO 92933

en Tanaka, Yujiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Investigative Surgery on 27/09/2017, available online: http://www.tandfonline.com/10.1080/08941939.2017.1366603.
キーワード
主題Scheme Other
主題 minimally invasive surgery
キーワード
主題Scheme Other
主題 animal model
キーワード
主題Scheme Other
主題 pneumoperitoneum
抄録
内容記述 Purpose: Experimental models of laparoscopic surgery generally use large animals owing to a sufficient abdominal working space. We developed a novel laparoscopic surgery model in rats. We performed intestinal anastomosis to demonstrate the feasibility and reliability of this model. Materials and Methods: We designed a device for rats that expanded the abdominal working space and allowed us to manipulate the intraperitoneal organs by hand under direct vision with pneumoperitoneum. We performed small bowel resection and intestinal anastomosis in rats using this model. To elucidate the effects of pneumoperitoneum and skin incision length, rats were randomly divided into four groups with differing surgical techniques: small incision group, large incision group, small incision + pneumoperitoneum group, and large incision + pneumoperitoneum group. Intraoperative abdominal pressure and postoperative cytokines were measured. Results: One experimenter completed small bowel resection and hand-sewn anastomosis under direct vision without any difficulties or assistance. Carbon dioxide pneumoperitoneum was maintained at 8–10 mmHg during surgery in both pneumoperitoneum groups. Necropsies revealed no evidence of anastomotic leakage at 24 h after surgery. The interleukin-6 and C-reactive protein concentrations were significantly greater in large incision group than in small incision group, but were not significantly different between small incision + pneumoperitoneum group and small incision group. These cytokines concentrations were the greatest in large incision + pneumoperitoneum group. Conclusions: Our laparoscopic surgery model in rats is a simple and reliable experimental model. The length of skin incision might be a more influential determinant of surgical invasiveness than pneumoperitoneum.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 Published online: 27 Sep 2017
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/08941939.2017.1366603
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0894-1939
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1521-0553
書誌情報 en : Journal of Investigative Surgery

巻 32, 号 1, p. 55-60, 発行日 2019
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