{"_buckets": {"deposit": "63a573b5-19d0-4b55-98c6-b2aaff8840e0"}, "_deposit": {"id": "28455", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28455"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028455"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "406", "bibliographicPageStart": "397", "bibliographicVolumeNumber": "81", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the maximum diameter, who were treated with HFSRT (mainly 35 Gy/5 fractions) in our center between 2006\u20132016, focusing on the effect of BM size on outcomes. Eligible patients were divided according to the maximum BM diameter (group A [23 patients]: \u22653 cm, group B [22 patients]: \u003c3 cm) to assess the relationship between tumor size and prognosis or safety. The primary outcome was the local control rate (LCR), and secondary outcomes were the response rate (RR), brain progression-free survival (BPFS), median survival time (MST), and radionecrosis (RN). Univariate and multivariate analyses for LCR were conducted using Cox\u2019s proportional hazards model. In the 45 eligible patients (58 lesions) enrolled in this study, the RR was 86.4% with an overall LCR of 64.7% at 12 months (67.1% for group A and 61.5% for group B [p = 0.45]). The median BPFS and MST were 11.6 and 14.2 months, respectively. Univariate analyses revealed that female patients and gynecological cancer patients had poorer LCR, but they were not significantly independent prognostic factors (p = 0.06, 0.09, respectively). Two patients (4.4%) experienced RN that was detected more than 4 years after HFSRT. We conclude that HFSRT is safe for large BM but further studies are needed to determine optimal doses and fractions.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.81.3.397", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html ", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN\uff08Online\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Koide, Yutaro"}], "nameIdentifiers": [{"nameIdentifier": "93121", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita, Natsuo"}], "nameIdentifiers": [{"nameIdentifier": "93122", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Adachi, Sou"}], "nameIdentifiers": [{"nameIdentifier": "93123", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "93124", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tachibana, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "93125", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodaira, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "93126", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "05_Koide.pdf", "filesize": [{"value": "618.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 618700.0, "url": {"label": "05_Koide.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/28455/files/05_Koide.pdf"}, "version_id": "9ecc09ef-d9ff-4597-92f3-d2cc7fa12c80"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "helical tomotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "stereotactic radiotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "radiosurgery", "subitem_subject_scheme": "Other"}, {"subitem_subject": "brain metastases", "subitem_subject_scheme": "Other"}, {"subitem_subject": "radiation necrosis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/2431"], "permalink_uri": "https://doi.org/10.18999/nagjms.81.3.397", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-09-04"}, "publish_date": "2019-09-04", "publish_status": "0", "recid": "28455", "relation": {}, "relation_version_is_last": true, "title": ["Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm"], "weko_shared_id": null}