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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(3)

Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm

https://doi.org/10.18999/nagjms.81.3.397
https://doi.org/10.18999/nagjms.81.3.397
764b33b0-38b2-4f29-b3df-83a6dffaf25e
名前 / ファイル ライセンス アクション
05_Koide.pdf 05_Koide.pdf (618.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-09-04
タイトル
タイトル Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm
著者 Koide, Yutaro

× Koide, Yutaro

WEKO 93121

Koide, Yutaro

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Tomita, Natsuo

× Tomita, Natsuo

WEKO 93122

Tomita, Natsuo

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Adachi, Sou

× Adachi, Sou

WEKO 93123

Adachi, Sou

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Tanaka, Hiroshi

× Tanaka, Hiroshi

WEKO 93124

Tanaka, Hiroshi

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Tachibana, Hiroyuki

× Tachibana, Hiroyuki

WEKO 93125

Tachibana, Hiroyuki

Search repository
Kodaira, Takeshi

× Kodaira, Takeshi

WEKO 93126

Kodaira, Takeshi

Search repository
キーワード
主題Scheme Other
主題 helical tomotherapy
キーワード
主題Scheme Other
主題 stereotactic radiotherapy
キーワード
主題Scheme Other
主題 radiosurgery
キーワード
主題Scheme Other
主題 brain metastases
キーワード
主題Scheme Other
主題 radiation necrosis
抄録
内容記述 Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the maximum diameter, who were treated with HFSRT (mainly 35 Gy/5 fractions) in our center between 2006–2016, focusing on the effect of BM size on outcomes. Eligible patients were divided according to the maximum BM diameter (group A [23 patients]: ≥3 cm, group B [22 patients]: <3 cm) to assess the relationship between tumor size and prognosis or safety. The primary outcome was the local control rate (LCR), and secondary outcomes were the response rate (RR), brain progression-free survival (BPFS), median survival time (MST), and radionecrosis (RN). Univariate and multivariate analyses for LCR were conducted using Cox’s proportional hazards model. In the 45 eligible patients (58 lesions) enrolled in this study, the RR was 86.4% with an overall LCR of 64.7% at 12 months (67.1% for group A and 61.5% for group B [p = 0.45]). The median BPFS and MST were 11.6 and 14.2 months, respectively. Univariate analyses revealed that female patients and gynecological cancer patients had poorer LCR, but they were not significantly independent prognostic factors (p = 0.06, 0.09, respectively). Two patients (4.4%) experienced RN that was detected more than 4 years after HFSRT. We conclude that HFSRT is safe for large BM but further studies are needed to determine optimal doses and fractions.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.3.397
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 3, p. 397-406, 発行日 2019-08
著者版フラグ
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