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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(3)

Tegafur and 5-fluorouracil levels in tears and changes in tear volume in long-term users of the oral anticancer drug S-1

https://doi.org/10.18999/nagjms.81.3.415
https://doi.org/10.18999/nagjms.81.3.415
ab91cdce-2309-4bc2-a70f-3a978b4ffbaa
名前 / ファイル ライセンス アクション
07_Kuriki.pdf 07_Kuriki.pdf (2.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-09-04
タイトル
タイトル Tegafur and 5-fluorouracil levels in tears and changes in tear volume in long-term users of the oral anticancer drug S-1
著者 Kuriki, Reiko

× Kuriki, Reiko

WEKO 93132

Kuriki, Reiko

Search repository
Hata, Tsuyoshi

× Hata, Tsuyoshi

WEKO 93133

Hata, Tsuyoshi

Search repository
Nakayama, Kinuyo

× Nakayama, Kinuyo

WEKO 93134

Nakayama, Kinuyo

Search repository
Ito, Yuichi

× Ito, Yuichi

WEKO 93135

Ito, Yuichi

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Misawa, Kazunari

× Misawa, Kazunari

WEKO 93136

Misawa, Kazunari

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Ito, Seiji

× Ito, Seiji

WEKO 93137

Ito, Seiji

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Tatematsu, Michiko

× Tatematsu, Michiko

WEKO 93138

Tatematsu, Michiko

Search repository
Kaneda, Norio

× Kaneda, Norio

WEKO 93139

Kaneda, Norio

Search repository
キーワード
主題Scheme Other
主題 S-1
キーワード
主題Scheme Other
主題 tegafur
キーワード
主題Scheme Other
主題 5-fluorouracil
キーワード
主題Scheme Other
主題 watering eyes
キーワード
主題Scheme Other
主題 LC-MS/MS
抄録
内容記述 Eye problems are an adverse reaction sometimes found in chemotherapy. Although not life-threatening, they can reduce patients’ quality of life. The highest incidence of eye problems is reported for the combination anticancer drug S-1 (tegafur–gimeracil–oteracil), and methods to prevent or treat the eye problems caused by this drug are presently lacking. To determine early detection methods and treatment for adverse ocular reactions, we measured changes in tear volume and levels of tegafur (FT) and 5-fluorouracil (5-FU), an active metabolite of FT, in the tears of patients with long-term use of S-1. A total of 11 patients receiving S-1 monotherapy as adjuvant chemotherapy after gastric cancer surgery were included. Tear volume and FT and 5-FU levels in tears were measured by liquid chromatography with tandem mass spectrometry during a maximum of 8 treatment cycles (48 weeks). For analysis, patients were divided into two groups: “watering eyes” (n=6, complaints of watering eyes at least once during the treatment period) and “no watering eyes” (n=5, no complaints of watering eyes). Both groups exhibited increased FT and 5-FU levels in tears upon initiation of S-1 treatment, and levels rapidly decreased upon discontinuation. Our findings suggest a relationship between FT level in tears and tear volume in patients with long-term S-1 use. The symptom of watering eyes may thus be linked to FT level in tears.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.3.415
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 3, p. 415-425, 発行日 2019-08
著者版フラグ
値 publisher
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