@article{oai:nagoya.repo.nii.ac.jp:00028459, author = {Kamiya, Mariko and Mori, Takeshi and Nomura, Mio and Inagaki, Takayuki and Nonogaki, Tunemasa and Nagatsu, Akito and Yamagishi, Yuka and Mikamo, Hiroshige and Ikeda, Yoshiaki}, issue = {3}, journal = {Nagoya Journal of Medical Science}, month = {Aug}, note = {Pseudomonas aeruginosa is capable of biofilm formation. In this study, we investigated the effects of aqueous Tradescantia pallida extract on Pseudomonas aeruginosa growth and biofilm formation. Aqueous Tradescantia pallida extracts significantly inhibited both bacterial growth and biofilm formation. However, methanolic Tradescantia pallida extracts inhibited neither. Aqueous Tradescantia pallida extracts were deactivated by heating but were not deactivated by light exposure. The ingredients retained the inhibitory effect on the bacterial growth and biofilm formation after ultrafiltration of aqueous Tradescantia pallida extract. Furthermore, polyphenol-rich Tradescantia pallida extracts inhibited bacterial growth, thus, polyphenols are possible to be an active ingredient. We observed the biofilm by scanning electron microscopy, and quantitative and qualitative differ-ences in the biofilm and cells morphology. Interestingly, the biofilm treated aqueous Tradescantia pallida extracts remained premature. We postulated that premature biofilm formation was due to the inhibition of swarming motility. Indeed, aqueous Tradescantia pallida extracts inhibited swarming motility. These results demonstrate that Peudomonas aeruginosa growth and biofilm formation are inhibited by aqueous Tradescantia pallida extracts.}, pages = {439--452}, title = {Tradescantia pallida extract inhibits biofilm formation in Pseudomonas aeruginosa}, volume = {81}, year = {2019} }