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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(3)

Polymorphisms in CPT1B and CPT2 have no significant effect on plasma carnitine levels in Japanese cancer patients

https://doi.org/10.18999/nagjms.81.3.477
https://doi.org/10.18999/nagjms.81.3.477
2249045f-4856-4549-8ee9-13fc63db30b2
名前 / ファイル ライセンス アクション
13_Hishida.pdf 13_Hishida.pdf (996.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-09-04
タイトル
タイトル Polymorphisms in CPT1B and CPT2 have no significant effect on plasma carnitine levels in Japanese cancer patients
著者 Hishida, Asahi

× Hishida, Asahi

WEKO 93186

Hishida, Asahi

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Watanabe, Ryosuke

× Watanabe, Ryosuke

WEKO 93187

Watanabe, Ryosuke

Search repository
Hattori, Yuta

× Hattori, Yuta

WEKO 93188

Hattori, Yuta

Search repository
Okugawa, Yoshinaga

× Okugawa, Yoshinaga

WEKO 93189

Okugawa, Yoshinaga

Search repository
Shirai, Yumiko

× Shirai, Yumiko

WEKO 93190

Shirai, Yumiko

Search repository
Miki, Chikao

× Miki, Chikao

WEKO 93191

Miki, Chikao

Search repository
キーワード
主題Scheme Other
主題 cancer palliative care
キーワード
主題Scheme Other
主題 carnitine
キーワード
主題Scheme Other
主題 CPT1B
キーワード
主題Scheme Other
主題 CPT2
キーワード
主題Scheme Other
主題 genetic polymorphisms
抄録
内容記述 Treatment of cancer patients undergoing chemotherapy with L-carnitine (LC) supplementation is becoming increasingly popular in the clinic. The present study aimed to examine the possible effects of polymorphisms in CPT1B and CPT2 (CPT1B G320D, S427C, c.282-18 C>T, and p.E531K, and CPT2V368I) on the plasma concentration of carnitine in humans. The subjects were the 218 participants of the Iga Cohort Study. Differences in plasma-free carnitine levels by genotype were examined. Genotyping was conducted by polymerase chain reaction with confronting two-pair primers (PCR-CTPP). The plasma carnitine levels were significantly higher in males (P<0.001; Student’s t-test), and there was no significant difference in plasma carnitine levels between the age groups (P=0.202; ANOVA). One-way ANOVA revealed the plasma levels of carnitine were neither significantly different by CPT1B G320D, S427C, c.282-18 C>T, or p.E531K, nor by CPT2 V368I genotypes (P=0.133, P=0.538, P=0.636, P=0.509, and P=0.398, respectively). When analysis of covariance (ANCOVA) adjusted for age and sex was applied, the plasma levels of carnitine were not statistically significantly different according to these genotypes (P=0.299, P=0.715, P=0.980, P=0.851, and P=0.674, respectively). The present study did not identify any statistically significant differences in plasma carnitine levels between subjects with different CPT1 and CPT2 genotypes, suggesting that there may be no need to tailor treatments to patients’ genotypes when determining the dose/amount of LC to be administered to cancer patients undergoing palliative care.
内容記述タイプ Abstract
内容記述
内容記述 This study was supported in part by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology, JSPS KAKENHI Grant Number JP (No. 25460745).
内容記述タイプ Other
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.3.477
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 3, p. 477-487, 発行日 2019-08
著者版フラグ
値 publisher
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