{"created":"2021-03-01T06:36:43.526628+00:00","id":28620,"links":{},"metadata":{"_buckets":{"deposit":"347bbf02-3db6-492c-aa06-d238a2964ec7"},"_deposit":{"id":"28620","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28620"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028620","sets":["499:500:501"]},"author_link":["93705","93706","93707","93708","93709","93710"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"259","bibliographicPageStart":"249","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Pathology International","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein and a member of the α2‐macroglobulin/C3,C4,C5 family of thioester‐containing proteins first identified as being expressed on blood cells, including activated T cells and platelets, and a subset of CD34 + bone marrow cells containing megakaryocyte progenitors. Although CD109 carries the biallelic platelet‐specific alloantigen Gov, the physiological functions or roles of CD109 in human disease remain largely unknown. It was recently demonstrated that CD109 is expressed in many malignant tumors, including various squamous cell carcinomas and adenocarcinomas, and plays a role as a multifunctional coreceptor. CD109 reportedly associates with transforming growth factor (TGF)‐β receptors and negatively regulates TGF‐β signaling in keratinocytes. Additionally, CD109 is potentially related to signal transducer and activator of transcription‐3 signaling and aberrant cell proliferation. In this review, we describe recent evidence of CD109‐specific significance in malignant tumors shown in mouse models and human tissues. Furthermore, we discuss the physiological functions of CD109 in vitro and in vivo, including results of phenotype analyses of CD109‐deficient mice exhibiting epidermal hyperplasia and osteopenia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Version of Record online: 20 June 2019. ファイル公開：2020-06-20","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/pin.12798","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: [Mii, S. , Enomoto, A. , Shiraki, Y. , Taki, T. , Murakumo, Y. and Takahashi, M. (2019), CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis. Pathol Int, 69: 249-259. doi:10.1111/pin.12798], which has been published in final form at [https://doi.org/10.1111/pin.12798]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"1320-5463","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mii, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Enomoto, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiraki, Yukihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taki, Tetsuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakumo, Yoshiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Masahide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93710","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-20"}],"displaytype":"detail","filename":"20191015_cd109_review.pdf","filesize":[{"value":"37.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20191015_cd109_review","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28620/files/20191015_cd109_review.pdf"},"version_id":"4f80e222-ffd3-44ce-89f6-28a36e55bcba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"carcinogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"CD109","subitem_subject_scheme":"Other"},{"subitem_subject":"exosome","subitem_subject_scheme":"Other"},{"subitem_subject":"glycosylphosphatidylinositol-anchored protein","subitem_subject_scheme":"Other"},{"subitem_subject":"malignant tumors","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse models","subitem_subject_scheme":"Other"},{"subitem_subject":"STAT3","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-10-15"},"publish_date":"2019-10-15","publish_status":"0","recid":"28620","relation_version_is_last":true,"title":["CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:21:35.453247+00:00"}