{"created":"2021-03-01T06:36:48.450611+00:00","id":28697,"links":{},"metadata":{"_buckets":{"deposit":"3c5354d2-cde0-4925-8426-b798ced3f5b8"},"_deposit":{"id":"28697","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28697"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028697","sets":["643:666:667"]},"author_link":["94195","94196","94197","94198","94199","94200","94201"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1978","bibliographicPageStart":"1971","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Journal of Natural Products","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Seven new cyclic depsipeptides, clavariopsins C–I (3–9), together with two known congeners, clavariopsins A and B (1 and 2), were isolated from the aquatic hyphomycete Clavariopsis aquatica. Their planar structures, which consist of nine amino acids and one α-hydroxy acid, were elucidated by NMR spectroscopy and HRESIMS. The absolute configurations were established by the advanced Marfey’s method and chiral-phase HPLC analysis. Their antifungal and cytotoxic activities were evaluated against six plant pathogenic fungi (Botrytis cinerea, Magnaporthe oryzae, Colletotrichum orbiculare, Fusarium oxysporum, Alternaria alternata, and Aspergillus niger) and a cancer cell line (HeLa-S3), respectively. The majority of the compounds exhibited potent antifungal activity against the fungi tested (minimum inhibition dose = 0.01–10 μg/disk) and induced hyphal swelling in A. niger (minimum effective dose = 0.3–3 μg/disk), whereas the compounds exhibited no cytotoxicity toward the cancer cell line. The results suggest that the clavariopsins could be a promising class of antifungal agents.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2020-07-26","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1021/acs.jnatprod.9b00366","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This document is the Accepted Manuscript version of a Published Work that appeared in final form in [Journal of Natural Products], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-tUsIHfzPbDUzbGeAcMhM].”","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0163-3864","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Soe, Thin Wut","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Han, Chunguang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fudou, Ryosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaida, Kenichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawaki, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomura, Tomohiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ojika, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94201","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-26"}],"displaytype":"detail","filename":"JNP_revised manuscript.pdf","filesize":[{"value":"846.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JNP_revised manuscript","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28697/files/JNP_revised manuscript.pdf"},"version_id":"3c8e6f00-57dd-41e6-a8ab-36dec14f58a3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clavariopsins C–I, Antifungal Cyclic Depsipeptides from the Aquatic Hyphomycete Clavariopsis aquatica","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clavariopsins C–I, Antifungal Cyclic Depsipeptides from the Aquatic Hyphomycete Clavariopsis aquatica","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["667"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-14"},"publish_date":"2019-11-14","publish_status":"0","recid":"28697","relation_version_is_last":true,"title":["Clavariopsins C–I, Antifungal Cyclic Depsipeptides from the Aquatic Hyphomycete Clavariopsis aquatica"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:21:41.840277+00:00"}