{"created":"2021-03-01T06:36:50.441141+00:00","id":28729,"links":{},"metadata":{"_buckets":{"deposit":"06f2adc2-9ff4-47d6-bab7-18c6e9095533"},"_deposit":{"id":"28729","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28729"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028729","sets":["499:500:501"]},"author_link":["94353","94354","94355","94356","94357","94358","94359","94360","94361","94362","94363","94364"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"e2698","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Human Psychopharmacology: Clinical and Experimental","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ファイル公開：2020-07-01","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/hup.2698","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: [ Miyauchi, T, Tokura, T, Kimura, H, et al. Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Hum Psychopharmacol Clin Exp. 2019; 34:e2698. https://doi.org/10.1002/hup.2698], which has been published in final form at [https://doi.org/10.1002/hup.2698]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0885-6222","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyauchi, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokura, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Mikiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umemura, Eri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato (Boku), Aiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagashima, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tonoike, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94360","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Yasuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94361","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Kuniaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurita, Kenichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozaki, Norio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94364","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-01"}],"displaytype":"detail","filename":"20190315_draft revised.pdf","filesize":[{"value":"304.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20190315_draft revised","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28729/files/20190315_draft revised.pdf"},"version_id":"8d469dbc-25d3-47c1-9f50-5d78f45135cd"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-01"}],"displaytype":"detail","filename":"Figure 1.pdf","filesize":[{"value":"8.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Figure 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pain","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-20"},"publish_date":"2019-11-20","publish_status":"0","recid":"28729","relation_version_is_last":true,"title":["Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:42:45.042086+00:00"}