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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Interconnection between circadian clocks and thyroid function

http://hdl.handle.net/2237/00031043
http://hdl.handle.net/2237/00031043
5c62ec9f-24d0-429b-b45a-5c9d26654f3c
名前 / ファイル ライセンス アクション
20191223NREND-18-170_Rev_Yoshimura.pdf 20191223NREND-18-170_Rev_Yoshimura (887.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-12-24
タイトル
タイトル Interconnection between circadian clocks and thyroid function
言語 en
著者 Ikegami, Keisuke

× Ikegami, Keisuke

WEKO 94964

en Ikegami, Keisuke

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Refetoff, Samuel

× Refetoff, Samuel

WEKO 94965

en Refetoff, Samuel

Search repository
Van Cauter, Eve

× Van Cauter, Eve

WEKO 94966

en Van Cauter, Eve

Search repository
Yoshimura, Takashi

× Yoshimura, Takashi

WEKO 94967

en Yoshimura, Takashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as ‘circadian clock genes’. In mammals, the central circadian pacemaker, which is located in the hypothalamic suprachiasmatic nucleus, controls peripheral circadian clocks. The circadian system regulates virtually all physiological processes, which are further modulated by changes in the external environment, such as light exposure and the timing of food intake. Chronic circadian disruption caused by shift work, travel across time zones or irregular sleep–wake cycles has long-term consequences for our health and is an important lifestyle factor that contributes to the risk of obesity, type 2 diabetes mellitus and cancer. Although the hypothalamic–pituitary–thyroid axis is under the control of the circadian clock via the suprachiasmatic nucleus pacemaker, daily TSH secretion profiles are disrupted in some patients with hypothyroidism and hyperthyroidism. Disruption of circadian rhythms has been recognized as a perturbation of the endocrine system and of cell cycle progression. Expression profiles of circadian clock genes are abnormal in well-differentiated thyroid cancer but not in the benign nodules or a healthy thyroid. Therefore, the characterization of the thyroid clock machinery might improve the preoperative diagnosis of thyroid cancer.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020/04/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Nature
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41574-019-0237-z
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1759-5029
書誌情報 en : Nature Reviews Endocrinology

巻 15, 号 10, p. 590-600, 発行日 2019-10
著者版フラグ
値 author
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