{"created":"2021-03-01T06:37:07.801363+00:00","id":28989,"links":{},"metadata":{"_buckets":{"deposit":"273c4ab9-3dd9-48fb-b49d-54d4c6715591"},"_deposit":{"id":"28989","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28989"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00028989","sets":["329:330:331"]},"author_link":["95226","95227","95228","95229","95230","95231","95232","95233","95234","95235","95236","95237","95238"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-09-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6459","bibliographicPageEnd":"1313","bibliographicPageStart":"1308","bibliographicVolumeNumber":"365","bibliographic_titles":[{"bibliographic_title":"Science","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone–producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake- and REM sleep–active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state–dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep–active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1126/science.aax9238","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"“This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science] on [v.365, n.6459, 20 Sep 2019], DOI: [10.1126/science.aai9057].”","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_61":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0036-8075","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Izawa, Shuntaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95226","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chowdhury, Srikanta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Toh","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mukai, Yasutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohmura, Yu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoguchi, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshioka, Mitsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Terao, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kilduff, Thomas S.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanaka, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95238","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-15"}],"displaytype":"detail","filename":"Izawa_combined.pdf","filesize":[{"value":"14.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Izawa_combined","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/28989/files/Izawa_combined.pdf"},"version_id":"73311f34-747c-4d01-97e4-36a0e2dc044d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["331"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-15"},"publish_date":"2020-01-15","publish_status":"0","recid":"28989","relation_version_is_last":true,"title":["REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T05:03:30.447865+00:00"}