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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin

http://hdl.handle.net/2237/00031187
http://hdl.handle.net/2237/00031187
140959ce-882c-47ee-8d12-a251f780cb9c
名前 / ファイル ライセンス アクション
Nagoya Nagoya Repository_Iida_Leukoderma_2020_1_15submit (9.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-01-15
タイトル
タイトル A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin
言語 en
著者 Iida, Machiko

× Iida, Machiko

WEKO 95252

en Iida, Machiko

Search repository
Tazaki, Akira

× Tazaki, Akira

WEKO 95253

en Tazaki, Akira

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Deng, Yuqi

× Deng, Yuqi

WEKO 95254

en Deng, Yuqi

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Chen, Wei

× Chen, Wei

WEKO 95255

en Chen, Wei

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Yajima, Ichiro

× Yajima, Ichiro

WEKO 95256

en Yajima, Ichiro

Search repository
Kondo-Ida, Lisa

× Kondo-Ida, Lisa

WEKO 95257

en Kondo-Ida, Lisa

Search repository
Hashimoto, Kazunori

× Hashimoto, Kazunori

WEKO 95258

en Hashimoto, Kazunori

Search repository
Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 95259

en Ohgami, Nobutaka

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 95260

en Kato, Masashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Chemical leukoderma
キーワード
主題Scheme Other
主題 Raspberry ketone
キーワード
主題Scheme Other
主題 Rhododenol
キーワード
主題Scheme Other
主題 Risk assessment
キーワード
主題Scheme Other
主題 Tail skin
抄録
内容記述 Chemical leukoderma is a patchy hypopigmentation in the skin. Phenol derivatives such as raspberry ketone have been reported to cause the development of occupationally induced leukoderma. Recently, 2% (w/w) rhododenol, a reduced form of raspberry ketone used in a skin-lightning agent, also caused the development of leukoderma in >16,000 users, about 2% of all users, in Asian countries including Japan. However, a method for assessing the risk of leukoderma caused by 2% rhododenol has not been established despite the fact that the development of leukoderma caused by 30% rhododenol was previously shown in animal experiments. Establishment of a novel technique for risk assessment of leukoderma in humans caused by external treatment with chemicals is needed to prevent a possible future chemical disaster. This study demonstrated that external treatment with 2% rhododenol and the same concentration of raspberry ketone caused the development of leukoderma in murine tail skin without exception with significant decreases in the amount of melanin and number of melanocytes in the epidermis. Thus, a novel in vivo technique that can assess the risk of leukoderma caused by 2% rhododenol was developed. The unique technique using tail skin has the potential to prevent chemical leukoderma in the future.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021-11-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.chemosphere.2019.06.185
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0045-6535
書誌情報 en : Chemosphere

巻 235, p. 713-718, 発行日 2019-11
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