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A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin
http://hdl.handle.net/2237/00031187
http://hdl.handle.net/2237/00031187140959ce-882c-47ee-8d12-a251f780cb9c
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-01-15 | |||||
タイトル | ||||||
タイトル | A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin | |||||
言語 | en | |||||
著者 |
Iida, Machiko
× Iida, Machiko× Tazaki, Akira× Deng, Yuqi× Chen, Wei× Yajima, Ichiro× Kondo-Ida, Lisa× Hashimoto, Kazunori× Ohgami, Nobutaka× Kato, Masashi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemical leukoderma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Raspberry ketone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rhododenol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Risk assessment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tail skin | |||||
抄録 | ||||||
内容記述 | Chemical leukoderma is a patchy hypopigmentation in the skin. Phenol derivatives such as raspberry ketone have been reported to cause the development of occupationally induced leukoderma. Recently, 2% (w/w) rhododenol, a reduced form of raspberry ketone used in a skin-lightning agent, also caused the development of leukoderma in >16,000 users, about 2% of all users, in Asian countries including Japan. However, a method for assessing the risk of leukoderma caused by 2% rhododenol has not been established despite the fact that the development of leukoderma caused by 30% rhododenol was previously shown in animal experiments. Establishment of a novel technique for risk assessment of leukoderma in humans caused by external treatment with chemicals is needed to prevent a possible future chemical disaster. This study demonstrated that external treatment with 2% rhododenol and the same concentration of raspberry ketone caused the development of leukoderma in murine tail skin without exception with significant decreases in the amount of melanin and number of melanocytes in the epidermis. Thus, a novel in vivo technique that can assess the risk of leukoderma caused by 2% rhododenol was developed. The unique technique using tail skin has the potential to prevent chemical leukoderma in the future. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2021-11-01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.chemosphere.2019.06.185 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0045-6535 | |||||
書誌情報 |
en : Chemosphere 巻 235, p. 713-718, 発行日 2019-11 |
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著者版フラグ | ||||||
値 | author |