{"_buckets": {"deposit": "54cf1037-3ddb-42b8-aed5-9d443bbd74ee"}, "_deposit": {"id": "29000", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "29000"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00029000"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-11", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "718", "bibliographicPageStart": "713", "bibliographicVolumeNumber": "235", "bibliographic_titles": [{"bibliographic_title": "Chemosphere"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Chemical leukoderma is a patchy hypopigmentation in the skin. Phenol derivatives such as raspberry ketone have been reported to cause the development of occupationally induced leukoderma. Recently, 2% (w/w) rhododenol, a reduced form of raspberry ketone used in a skin-lightning agent, also caused the development of leukoderma in \u003e16,000 users, about 2% of all users, in Asian countries including Japan. However, a method for assessing the risk of leukoderma caused by 2% rhododenol has not been established despite the fact that the development of leukoderma caused by 30% rhododenol was previously shown in animal experiments. Establishment of a novel technique for risk assessment of leukoderma in humans caused by external treatment with chemicals is needed to prevent a possible future chemical disaster. This study demonstrated that external treatment with 2% rhododenol and the same concentration of raspberry ketone caused the development of leukoderma in murine tail skin without exception with significant decreases in the amount of melanin and number of melanocytes in the epidermis. Thus, a novel in vivo technique that can assess the risk of leukoderma caused by 2% rhododenol was developed. The unique technique using tail skin has the potential to prevent chemical leukoderma in the future.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2021-11-01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.chemosphere.2019.06.185", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0045-6535", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Iida, Machiko"}], "nameIdentifiers": [{"nameIdentifier": "95252", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tazaki, Akira"}], "nameIdentifiers": [{"nameIdentifier": "95253", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Deng, Yuqi"}], "nameIdentifiers": [{"nameIdentifier": "95254", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chen, Wei"}], "nameIdentifiers": [{"nameIdentifier": "95255", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yajima, Ichiro"}], "nameIdentifiers": [{"nameIdentifier": "95256", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo-Ida, Lisa"}], "nameIdentifiers": [{"nameIdentifier": "95257", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "95258", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohgami, Nobutaka"}], "nameIdentifiers": [{"nameIdentifier": "95259", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "95260", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-11-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2021/11/1.", "file_order": 0, "filename": "Nagoya Repository_Iida_Leukoderma_2020_1_15submit.pdf", "filesize": [{"value": "9.6 MB"}], "format": "application/pdf", "future_date_message": "Download is available from 2021/11/1.", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 9600000.0, "url": {"label": "Nagoya Repository_Iida_Leukoderma_2020_1_15submit", "url": "https://nagoya.repo.nii.ac.jp/record/29000/files/Nagoya Repository_Iida_Leukoderma_2020_1_15submit.pdf"}, "version_id": "c4bfbaf2-2d3b-4a7f-80f7-3e8d1d038f5a"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Chemical leukoderma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Raspberry ketone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rhododenol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Risk assessment", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tail skin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00031187", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2020-01-15"}, "publish_date": "2020-01-15", "publish_status": "0", "recid": "29000", "relation": {}, "relation_version_is_last": true, "title": ["A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin"], "weko_shared_id": null}